CD8A
| CD8A | |||
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Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process |
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| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
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| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 2: 86.78 – 86.81 Mb | Chr 6: 71.35 – 71.36 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
CD8a (Cluster of Differentiation 8a), is a human gene.[5]
Function
The CD8 antigen is a cell surface
class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain isoforms. Two alternative transcripts encoding distinct isoforms, one membrane associated and one secreted, have been identified.[5]
Interactions
CD8A has been shown to interact with:
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000153563 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000053977 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: CD8A CD8a molecule".
- PMID 12215456.
- ^ PMID 10809759.
- S2CID 4267617.
- PMID 1908512.
Further reading
- Parnes JR (1989). Molecular Biology and Function of CD4 and CD8. Advances in Immunology. Vol. 44. pp. 265–311. PMID 2493728.
- Li L, Li HS, Pauza CD, Bukrinsky M, Zhao RY (2006). "Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions". Cell Res. 15 (11–12): 923–34. PMID 16354571.
- Stove V, Verhasselt B (2006). "Modelling thymic HIV-1 Nef effects". Curr. HIV Res. 4 (1): 57–64. PMID 16454711.
- Nakayama K, Kawachi Y, Tokito S, Minami N, Yamamoto R, Imai T, Gachelin G, Nakauchi H (1992). "Recent duplication of the two human CD8 beta-chain genes". J. Immunol. 148 (6): 1919–27. S2CID 8993127.
- Leahy DJ, Axel R, Hendrickson WA (1992). "Crystal structure of a soluble form of the human T cell coreceptor CD8 at 2.6 A resolution". Cell. 68 (6): 1145–62. S2CID 6261613.
- Erickson JD, Trojanowski JQ, Eiden LE (1991). "Regional distribution and partial molecular characterization of CD4-related mRNA in human brain and peripheral tissues". Brain Res. Mol. Brain Res. 10 (1): 23–31. PMID 1676132.
- Moebius U, Kober G, Griscelli AL, Hercend T, Meuer SC (1991). "Expression of different CD8 isoforms on distinct human lymphocyte subpopulations". Eur. J. Immunol. 21 (8): 1793–800. S2CID 46227655.
- Mittler RS, Rankin BM, Kiener PA (1991). "Physical associations between CD45 and CD4 or CD8 occur as late activation events in antigen receptor-stimulated human T cells". J. Immunol. 147 (10): 3434–40. S2CID 21291442.
- Sanders SK, Giblin PA, Kavathas P (1991). "Cell-cell adhesion mediated by CD8 and human histocompatibility leukocyte antigen G, a nonclassical major histocompatibility complex class 1 molecule on cytotrophoblasts". J. Exp. Med. 174 (3): 737–40. PMID 1908512.
- Barber EK, Dasgupta JD, Schlossman SF, Trevillyan JM, Rudd CE (1989). "The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex". Proc. Natl. Acad. Sci. U.S.A. 86 (9): 3277–81. PMID 2470098.
- Norment AM, Lonberg N, Lacy E, Littman DR (1989). "Alternatively spliced mRNA encodes a secreted form of human CD8 alpha. Characterization of the human CD8 alpha gene". J. Immunol. 142 (9): 3312–9. S2CID 23835202.
- Nakayama K, Tokito S, Okumura K, Nakauchi H (1989). "Structure and expression of the gene encoding CD8 alpha chain (Leu-2/T8)". Immunogenetics. 30 (5): 393–7. S2CID 42149394.
- Giblin P, Ledbetter JA, Kavathas P (1989). "A secreted form of the human lymphocyte cell surface molecule CD8 arises from alternative splicing". Proc. Natl. Acad. Sci. U.S.A. 86 (3): 998–1002. PMID 2536941.
- Aruffo A, Seed B (1989). "Expression of cDNA clones encoding the thymocyte antigens CD1a, b, c demonstrates a hierarchy of exclusion in fibroblasts". J. Immunol. 143 (5): 1723–30. S2CID 23168239.
- Bowcock AM, Kavathas P, Margolskee RF, Herzenberg L, Cavalli-Sforza LL (1986). "An RFLP associated with pcDLeu2-14, a human T-cell differentiation antigen CD8 (Leu2) cDNA mapped to 2p12". Nucleic Acids Res. 14 (19): 7817. PMID 2877435.
- Norment AM, Littman DR (1989). "A second subunit of CD8 is expressed in human T cells". EMBO J. 7 (11): 3433–9. PMID 3145195.
- Littman DR, Thomas Y, Maddon PJ, Chess L, Axel R (1985). "The isolation and sequence of the gene encoding T8: a molecule defining functional classes of T lymphocytes". Cell. 40 (2): 237–46. S2CID 35066139.
- Sukhatme VP, Sizer KC, Vollmer AC, Hunkapiller T, Parnes JR (1985). "The T cell differentiation antigen Leu-2/T8 is homologous to immunoglobulin and T cell receptor variable regions". Cell. 40 (3): 591–7. S2CID 22206011.
- Parnes JR, Sizer KC, Sukhatme VP, Hunkapiller T (1986). "Structure of Leu-2/T8 as deduced from the sequence of a cDNA clone". Behring Inst. Mitt. (77): 48–55. PMID 3936473.
External links
- CD8a+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Human CD8A genome location and CD8A gene details page in the UCSC Genome Browser.
- Human MAL genome location and MAL gene details page in the UCSC Genome Browser.
- Overview of all the structural information available in the PDB for UniProt: P01732 (Human T-cell surface glycoprotein CD8 alpha chain) at the PDBe-KB.
- Overview of all the structural information available in the PDB for UniProt: P01731 (Mouse T-cell surface glycoprotein CD8 alpha chain) at the PDBe-KB.
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