CD8
Putative T-cell surface glycoprotein CD8 | |
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Identifiers | |
Symbol | CD8 |
Membranome | 29 |
Chr. 2 p12 | |||||||
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CD8b molecule | |||||||
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Identifiers | |||||||
Symbol | CD8B | ||||||
Alt. symbols | CD8B1 | ||||||
Chr. 2 p12 | |||||||
|
CD8 (cluster of differentiation 8) is a transmembrane glycoprotein that serves as a co-receptor for the T-cell receptor (TCR). Along with the TCR, the CD8 co-receptor plays a role in T cell signaling and aiding with cytotoxic T cell-antigen interactions.
Like the TCR, CD8 binds to a major histocompatibility complex (MHC) molecule, but is specific for the MHC class I protein.[1]
There are two isoforms of the protein, alpha and beta, each encoded by a different gene. In humans, both genes are located on chromosome 2 in position 2p12.
Tissue distribution
The CD8 co-receptor is predominantly expressed on the surface of cytotoxic T cells, but can also be found on natural killer cells, cortical thymocytes, and dendritic cells. The CD8 molecule is a marker for cytotoxic T cell population. It is expressed in T cell lymphoblastic lymphoma and hypo-pigmented mycosis fungoides.[2]
Structure
To function, CD8 forms a dimer, consisting of a pair of CD8 chains. The most common form of CD8 is composed of a CD8-α and CD8-β chain, both members of the
Function
The extracellular IgV-like domain of CD8-α interacts with the α3 portion of the Class I MHC molecule.
References
- PMID 11114424.
- ISBN 1-84110-100-1.
- ^ "anti-Human CD8" (PDF). Bangs Laboratories, Inc. 21 March 2013. Archived (PDF) from the original on 2016-10-13. Retrieved 2016-08-18.
- ^ S2CID 6261613.
- S2CID 83819031.
- ^ "CD8 alpha - Marker for cytotoxic T Lymphocytes". Archived from the original on 21 September 2015. Retrieved 11 January 2016.
External links
- T-cell Group - Cardiff University
- Mouse CD Antigen Chart
- Human CD Antigen Chart
- CD8 alpha - Marker for cytotoxic T lymphocytes [1]
- ^ "CD8 alpha - Marker for cytotoxic T lymphocytes". Archived from the original on 2015-09-21.