CEBPD

Source: Wikipedia, the free encyclopedia.
CEBPD
Identifiers
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Ensembl
UniProt
RefSeq (mRNA)

NM_005195

NM_007679

RefSeq (protein)

NP_005186

NP_031705

Location (UCSC)Chr 8: 47.74 – 47.74 MbChr 16: 15.71 – 15.71 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CCAAT/enhancer-binding protein delta is a protein that in humans is encoded by the CEBPD gene.[5][6]

Function

The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages.[7]

Functions

CEBPD is involved in regulation of apoptosis and cell proliferation. It probably acts as tumor suppressor.[8]

One study in mice showed that CEBPD prevents development of tubular injury and tubulointerstitial fibrogenesis during the progression of chronic obstructive nephropathy.[9]

Function of CEBPD gene can be effectively examined by siRNA knockdown based on an independent validation.[10]

Interactions

CEBPD has been shown to

See also

  • Ccaat-enhancer-binding proteins

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000221869 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000071637 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. PMID 1840554
    .
  6. .
  7. ^ "Entrez Gene: CEBPD CCAAT/enhancer binding protein (C/EBP), delta".
  8. S2CID 24347537
    .
  9. .
  10. .
  11. .

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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