CEBPG
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| Location (UCSC) | Chr 19: 33.37 – 33.38 Mb | Chr 7: 34.75 – 34.76 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
CCAAT/enhancer-binding protein gamma (C/EBPγ) is a protein that in humans is encoded by the CEBPG gene.[5][6] This gene has no introns.
The
C/EBPζ, and C/EBPε, that form homodimers and that form heterodimers with each other. CCAAT/enhancer binding protein gamma may cooperate with Fos to bind the positive regulatory element-I (PRE-I) enhancer elements.[6][7]
C/EBPγ forms heterodimer with
amino acid starvation.[8]
C/EBPγ along with its regulator, the trauma-induced transcription factor EGR1, plays an important role in the development of chronic pain and mechanical hypersensitivity after some types of injury or surgery.[9][10]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000153879 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000056216 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 1884998.
- ^ a b "Entrez Gene: CEBPG CCAAT/enhancer binding protein (C/EBP), gamma".
- PMID 7665092.
- PMID 35801910.
- S2CID 29286007.
- )
Further reading
- Nishizawa M, Nagata S (1992). "cDNA clones encoding leucine-zipper proteins which interact with G-CSF gene promoter element 1-binding protein". FEBS Lett. 299 (1): 36–8. S2CID 34097395.
- Thomassin H, Hamel D, Bernier D, et al. (1992). "Molecular cloning of two C/EBP-related proteins that bind to the promoter and the enhancer of the alpha 1-fetoprotein gene. Further analysis of C/EBP beta and C/EBP gamma". Nucleic Acids Res. 20 (12): 3091–8. PMID 1377818.
- Nishizawa M, Wakabayashi-Ito N, Nagata S (1991). "Molecular cloning of cDNA and a chromosomal gene encoding GPE1-BP, a nuclear protein which binds to granulocyte colony-stimulating factor promoter element 1". FEBS Lett. 282 (1): 95–7. S2CID 948618.
- Cooper C, Henderson A, Artandi S, et al. (1996). "Ig/EBP (C/EBP gamma) is a transdominant negative inhibitor of C/EBP family transcriptional activators". Nucleic Acids Res. 23 (21): 4371–7. PMID 7501458.
- Lundgren M, Larsson C, Femino A, et al. (1994). "Activation of the Ig germ-line gamma 1 promoter. Involvement of C/enhancer-binding protein transcription factors and their possible interaction with an NF-IL-4 site". J. Immunol. 153 (7): 2983–95. S2CID 24982598.
- Martin ML, Lieberman PM, Curran T (1996). "Fos-Jun dimerization promotes interaction of the basic region with TFIIE-34 and TFIIF". Mol. Cell. Biol. 16 (5): 2110–8. PMID 8628277.
- Gao H, Parkin S, Johnson PF, Schwartz RC (2002). "C/EBP gamma has a stimulatory role on the IL-6 and IL-8 promoters". J. Biol. Chem. 277 (41): 38827–37. PMID 12177065.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932.
- Hattori T, Ohoka N, Inoue Y, et al. (2003). "C/EBP family transcription factors are degraded by the proteasome but stabilized by forming dimer". Oncogene. 22 (9): 1273–80. S2CID 1351748.
- Newman JR, Keating AE (2003). "Comprehensive identification of human bZIP interactions with coiled-coil arrays". Science. 300 (5628): 2097–101. S2CID 36715183.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMID 15489334.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. S2CID 4427026.
- Mullins DN, Crawford EL, Khuder SA, et al. (2006). "CEBPG transcription factor correlates with antioxidant and DNA repair genes in normal bronchial epithelial cells but not in individuals with bronchogenic carcinoma". BMC Cancer. 5: 141. PMID 16255782.
External links
- CEBPG+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Human CEBPG genome location and CEBPG gene details page in the UCSC Genome Browser.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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