CMX521

CMX521
Legal status
Legal status	US: Investigational drug;
Identifiers
	IUPAC name 4-amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-methylpyrrolo[2,3-d]pyrimidine-5-carboxamide;
JSmol)	Interactive image;
	SMILES CC1=NC(=C2C(=CN(C2=N1)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)C(=O)N)N;
	InChI InChI=1S/C13H17N5O5/c1-4-16-10(14)7-5(11(15)22)2-18(12(7)17-4)13-9(21)8(20)6(3-19)23-13/h2,6,8-9,13,19-21H,3H2,1H3,(H2,15,22)(H2,14,16,17)/t6-,8-,9-,13-/m1/s1; Key:PMQFVTNOZQVIOK-HTVVRFAVSA-N;

CMX521 is an

adenoviruses. It is a nucleoside analogue which acts as an inhibitor of viral RNA-dependant RNA polymerase.^[1]^[2]^[3]

References

PMID 30791582
.

PMID 30584800
.

PMID 33375298
.

4A
protease inhibitors (–previr)

Asunaprevir

Boceprevir^‡

Ciluprevir^§

Danoprevir^†

Faldaprevir^‡

Glecaprevir

Grazoprevir

Narlaprevir

Paritaprevir

Simeprevir

Sovaprevir^†

Telaprevir^‡

Vaniprevir

Vedroprevir^§

Voxilaprevir

NS5A
inhibitors (–asvir)

Coblopasvir

Daclatasvir^#

Elbasvir

Ledipasvir

Odalasvir^†

Ombitasvir

Pibrentasvir

Ravidasvir^†

Ruzasvir^†

Samatasvir^†

Velpatasvir

NS5B RNA polymerase
inhibitors (–buvir)

Beclabuvir^†

Bemnifosbuvir^†

Dasabuvir^#

Deleobuvir^§

Filibuvir^§

GS-6620^§

IDX-184^§

Setrobuvir^§

Sofosbuvir^#

Tegobuvir^§

TMC-647055^§

Radalbuvir^†

Uprifosbuvir^†

Combination drugs

Elbasvir/grazoprevir

Glecaprevir/pibrentasvir

Ledipasvir/sofosbuvir^#

Ombitasvir/paritaprevir/ritonavir^#

Sofosbuvir/daclatasvir

Sofosbuvir/velpatasvir^#

Sofosbuvir/velpatasvir/voxilaprevir

Hepatitis D

Bulevirtide

Picornavirus

viral entry: Pleconaril^†

Anti-influenza agents

Baloxavir marboxil

Pimodivir^†

Umifenovir

M2 inhibitors (Adapromine

Amantadine

Rimantadine)

neuraminidase inhibitors/release phase (Oseltamivir^#

Zanamivir

Peramivir, Laninamivir^†)

Multiple/general
Interferon

Interferon alfa 2b

Peginterferon alfa-2a^#

Peginterferon alfa-2b^#

3CL protease inhibitors (–trelvir)

Ensitrelvir^†

Lufotrelvir

Nirmatrelvir^† (+ritonavir)^†

Rupintrivir

Simnotrelvir (+ritonavir
^†)

RNA pol inhibitors

CMX521^§

Deuremidevir^†

Favipiravir

Galidesivir^†

GS-441524^§

Remdesivir

MK-608^§

Mericitabine^†

Molnupiravir

NITD008^§

Ribavirin^#

Taribavirin^†

Triazavirin

Valopicitabine^†

Multiple/Unknown/Other

EICAR^§

Merimepodib^§

Moroxydine

Presatovir^†

^#WHO-EM

^‡Withdrawn from market

Clinical trials:
^†Phase III

^§Never to phase III

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v
t
e

[1] PMID 30791582
.

[2] PMID 30584800
.

[pmid33375298-3] PMID 33375298
.

[1]

[2]

[3]

See also

References