COVID-19 pandemic

COVID-19 pandemic
Medical professionals treating a COVID-19 patient in critical condition in an intensive care unit in São Paulo in May 2020
Confirmed deaths per 100,000 population as of 19 May 2023
Cases per capita Cumulative percentage of population infected as of 19 March 2022   >10%   3–10%   1–3%   0.3–1%   0.1–0.3%   0.03–0.1%   0–0.03%   None or no data
Disease	Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2)
Source	Bats,[1] indirectly[2]
Location	Worldwide
Index case	Wuhan, China 30°37′11″N 114°15′28″E / 30.61972°N 114.25778°E / 30.61972; 114.25778 Public health emergency of international concern: 30 January 2020 – 5 May 2023 (3 years, 3 months and 5 days)
Confirmed cases	770,777,632[3]
Deaths	6,958,486[3] (reported) 17.5–31.4 million[4] (estimated)
Fatality rate	1.02%[5]

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The COVID-19 pandemic, also known as the coronavirus pandemic, is a global

In epidemiology, a pandemic is defined as "an epidemic occurring over a very wide area, crossing international boundaries, and usually affecting a large number of people". During the COVID-19 pandemic, as with other pandemics, the meaning of this term has been challenged.^[8]

During the initial outbreak in Wuhan, the virus and disease were commonly referred to as "coronavirus", "Wuhan coronavirus",^[9] "the coronavirus outbreak" and the "Wuhan coronavirus outbreak",^[10] with the disease sometimes called "Wuhan pneumonia".^[11][12] In January 2020, the WHO recommended 2019-nCoV^[13] and 2019-nCoV acute respiratory disease^[14] as interim names for the virus and disease per 2015 international guidelines against using geographical locations (e.g. Wuhan, China), animal species, or groups of people in disease and virus names in part to prevent social stigma.^[15] WHO finalized the official names COVID-19 and SARS-CoV-2 on 11 February 2020.^[16] Tedros Adhanom Ghebreyesus explained: CO for corona, VI for virus, D for disease and 19 for when the outbreak was first identified (31 December 2019).^[17] WHO additionally uses "the COVID-19 virus" and "the virus responsible for COVID-19" in public communications.^[16]

WHO named

Epidemiology

For country-level data, see:

COVID-19 pandemic by country and territory

Cases 770,777,632[3] Deaths 6,958,486[3] As of 27 September 2023 Africa Asia Europe North America Oceania South America Antarctica

Background

SARS-CoV-2 is a virus closely related to

The earliest known infected person fell ill on 1 December 2019. That individual did not have a connection with the later wet market cluster.^[34][35] However, an earlier case may have occurred on 17 November.^[36] Two-thirds of the initial case cluster were linked with the market.^[37][38][39] Molecular clock analysis suggests that the index case is likely to have been infected between mid-October and mid-November 2019.^[40][41]

Cases

Official "case" counts refer to the number of people who have been tested for COVID-19 and whose test has been confirmed positive according to official protocols whether or not they experienced symptomatic disease.^[42][43] Due to the effect of sampling bias, studies which obtain a more accurate number by extrapolating from a random sample have consistently found that total infections considerably exceed the reported case counts.^[44][45] Many countries, early on, had official policies to not test those with only mild symptoms.^[46][47] The strongest risk factors for severe illness are obesity, complications of diabetes, anxiety disorders, and the total number of conditions.^[48]

During the start of the COVID-19 pandemic it was not clear whether young people were less likely to be infected, or less likely to develop symptoms and be tested.^[49] A retrospective cohort study in China found that children and adults were just as likely to be infected.^[50]

Among more thorough studies,

Initial estimates of the basic reproduction number (R₀) for COVID-19 in January 2020 were between 1.4 and 2.5,^[55] but a subsequent analysis claimed that it may be about 5.7 (with a 95 percent confidence interval of 3.8 to 8.9).^[56]

In December 2021, the number of cases continued to climb due to several factors, including new COVID-19 variants. As of that 28 December, 282,790,822 individuals worldwide had been confirmed as infected.^[57] As of 14 April 2022^[update], over 500 million cases were confirmed globally.^[58] Most cases are unconfirmed, with the Institute for Health Metrics and Evaluation estimating the true number of cases as of early 2022 to be in the billions.^[59][60]

Deaths

As of 10 March 2023, more than 6.88 million^[5] deaths had been attributed to COVID-19. The first confirmed death was in Wuhan on 9 January 2020.^[62] These numbers vary by region and over time, influenced by testing volume, healthcare system quality, treatment options, government response,^[63] time since the initial outbreak, and population characteristics, such as age, sex, and overall health.^[64]

Multiple measures are used to quantify mortality.^[65] Official death counts typically include people who died after testing positive. Such counts exclude deaths without a test.^[66] Conversely, deaths of people who died from underlying conditions following a positive test may be included.^[67] Countries such as Belgium include deaths from suspected cases, including those without a test, thereby increasing counts.^[68]

Official death counts have been claimed to underreport the actual death toll, because

In May 2022, the WHO estimated the number of excess deaths by the end of 2021 to be 14.9 million compared to 5.4 million reported COVID-19 deaths, with the majority of the unreported 9.5 million deaths believed to be direct deaths due the virus, rather than indirect deaths. Some deaths were because people with other conditions could not access medical services.^[74][75]

A December 2022

The time between symptom onset and death ranges from 6 to 41 days, typically about 14 days.[78] Mortality rates increase as a function of age. People at the greatest mortality risk are the elderly and those with underlying conditions.^[79][80]

• 

  Semi-log plot of weekly deaths due to COVID-19 in the world and top six current countries (mean with cases)

• 

  Excess deaths relative to expected deaths (The patterns indicate the quality of the all-cause mortality data that were available for each respective country.)^[61]

• 

  Excess deaths relative to expected deaths (global and WHO region)^[61]

• 

  The 25 countries with the highest total estimated COVID-19 pandemic excess deaths between January 2020 and December 2021^[61]

• 

  The 25 countries with the highest mean P-scores (excess deaths relative to expected deaths)^[61]

Infection fatality ratio (IFR)

The

In December 2020, a systematic review and meta-analysis estimated that population-weighted IFR was 0.5% to 1% in some countries (France, Netherlands, New Zealand, and Portugal), 1% to 2% in other countries (Australia, England, Lithuania, and Spain), and about 2.5% in Italy. This study reported that most of the differences reflected corresponding differences in the population's age structure and the age-specific pattern of infections.[81] There have also been reviews that have compared the fatality rate of this pandemic with prior pandemics, such as MERS-CoV.^[89]

For comparison the infection mortality rate of seasonal flu in the United States is 0.1%, which is 13 times lower than COVID-19.^[90]

Case fatality ratio (CFR)

Another metric in assessing death rate is the case fatality ratio (CFR),^[a] which is the ratio of deaths to diagnoses. This metric can be misleading because of the delay between symptom onset and death and because testing focuses on symptomatic individuals.^[91]

Based on Johns Hopkins University statistics, the global CFR is 1.02 percent (6,881,955 deaths for 676,609,955 cases) as of 10 March 2023.^[5] The number varies by region and has generally declined over time.^[92]

Disease

Variants

Several variants have been named by WHO and labelled as a

Signs and symptoms

Symptoms of COVID-19 are variable, ranging from mild symptoms to severe illness.

The disease is mainly transmitted via the respiratory route when people inhale droplets and small airborne particles (that form an aerosol) that infected people exhale as they breathe, talk, cough, sneeze, or sing.^{[103][104][105][106]} Infected people are more likely to transmit COVID-19 when they are physically close to other non-infected individuals. However, infection can occur over longer distances, particularly indoors.^[103][107]

Cause

SARS‑CoV‑2 belongs to the broad family of viruses known as

The standard method of testing for presence of SARS-CoV-2 is a nucleic acid test,^[111] which detects the presence of viral RNA fragments.^[112] As these tests detect RNA but not infectious virus, its "ability to determine duration of infectivity of patients is limited."^[113] The test is typically done on respiratory samples obtained by a nasopharyngeal swab; however, a nasal swab or sputum sample may also be used.^[114][115] The WHO has published several testing protocols for the disease.^[116]

Prevention

Preventive measures to reduce the chances of infection include getting vaccinated, staying at home or spending more time outdoors, avoiding crowded places, keeping distance from others, wearing a mask in public, ventilating indoor spaces, managing potential exposure durations, washing hands with soap and water often and for at least twenty seconds, practicing good respiratory hygiene, and avoiding touching the eyes, nose, or mouth with unwashed hands.^[117][118]

Those diagnosed with COVID-19 or who believe they may be infected are advised by healthcare authorities to stay home except to get medical care, call ahead before visiting a healthcare provider, wear a face mask before entering the healthcare provider's office and when in any room or vehicle with another person, cover coughs and sneezes with a tissue, regularly wash hands with soap and water and avoid sharing personal household items.^{[119][120][121]}

Vaccines

A COVID-19

As of March 2023, more than 5.5 billion people had received one or more doses[126] (11.8 billion in total) in over 197 countries. The Oxford-AstraZeneca vaccine was the most widely used.^[127] According to a June 2022 study, COVID-19 vaccines prevented an additional 14.4 million to 19.8 million deaths in 185 countries and territories from 8 December 2020 to 8 December 2021.^[128][129]

On 8 November 2022, the first recombinant protein-based COVID-19 vaccine (Novavax's booster

On 12 November 2022, the WHO released its Global Vaccine Market Report. The report indicated that "inequitable distribution is not unique to COVID-19 vaccines"; countries that are not economically strong struggle to obtain vaccines.[132]

On 14 November 2022, the first inhalable vaccine was introduced, developed by Chinese biopharmaceutical company CanSino Biologics, in the city of Shanghai, China.^[133]

Treatment

For the first two years of the pandemic, no specific and effective treatment or cure was available.

Existing drugs such as hydroxychloroquine, lopinavir/ritonavir, and ivermectin are not recommended by US or European health authorities, as there is no good evidence they have any useful effect.^{[134][146][147]} The antiviral remdesivir is available in the US, Canada, Australia, and several other countries, with varying restrictions; however, it is not recommended for use with mechanical ventilation, and is discouraged altogether by the World Health Organization (WHO),^[148] due to limited evidence of its efficacy.^[134]

Prognosis

The severity of COVID-19 varies. It may take a mild course with few or no symptoms, resembling other common upper respiratory diseases such as the

Nature reported in 2021 that 90 percent of researchers who responded to a survey "think that the coronavirus will become endemic".^[165]

Containment

Containment is undertaken to stop an outbreak from spreading into the general population. Infected individuals are isolated while they are infectious. The people they have interacted with are contacted and isolated for long enough to ensure that they are either not infected or no longer contagious. Screening is the starting point for containment. Screening is done by checking for symptoms to identify infected individuals, who can then be isolated or offered treatment.

Should containment fail, efforts focus on mitigation: measures taken to slow the spread and limit its effects on the healthcare system and society. Successful mitigation delays and decreases the epidemic peak, known as "flattening the epidemic curve".^[159] This decreases the risk of overwhelming health services and provides more time for developing vaccines and treatments.^[159] Individual behaviour changed in many jurisdictions. Many people worked from home instead of at their traditional workplaces.^[169]

Non-pharmaceutical interventions

Non-pharmaceutical interventions that may reduce spread include personal actions such as wearing face masks, self-quarantine, and hand hygiene; community measures aimed at reducing interpersonal contacts such as closing workplaces and schools and cancelling large gatherings; community engagement to encourage acceptance and participation in such interventions; as well as environmental measures such as surface cleaning.^[170]

Other measures

More drastic actions, such as quarantining entire populations and strict travel bans have been attempted in various jurisdictions.

Contact tracing attempts to identify recent contacts of newly infected individuals, and to screen them for infection; the traditional approach is to request a list of contacts from infectees, and then telephone or visit the contacts.^[173] Contact tracing was widely used during the Western African Ebola virus epidemic in 2014.^[174]

Another approach is to collect location data from mobile devices to identify those who have come in significant contact with infectees, which prompted privacy concerns.^[175] On 10 April 2020, Google and Apple announced an initiative for privacy-preserving contact tracing.^[176][177] In Europe and in the US, Palantir Technologies initially provided COVID-19 tracking services.^[178]

Health care

WHO described increasing capacity and adapting healthcare as a fundamental mitigation.^[179] The ECDC and WHO's European regional office issued guidelines for hospitals and primary healthcare services for shifting resources at multiple levels, including focusing laboratory services towards testing, cancelling elective procedures, separating and isolating patients, and increasing intensive care capabilities by training personnel and increasing ventilators and beds.^[179][180] The pandemic drove widespread adoption of telehealth.^[181]

Improvised manufacturing

Due to supply chain capacity limitations, some manufacturers began 3D printing material such as nasal swabs and ventilator parts.^[182][183] In one example, an Italian startup received legal threats due to alleged patent infringement after reverse-engineering and printing one hundred requested ventilator valves overnight.^[184] Individuals and groups of makers created and shared open source designs, and manufacturing devices using locally sourced materials, sewing, and 3D printing. Millions of face shields, protective gowns, and masks were made. Other ad hoc medical supplies included shoe covers, surgical caps, powered air-purifying respirators, and hand sanitizer. Novel devices were created such as ear savers, non-invasive ventilation helmets, and ventilator splitters.^[185]

Herd immunity

In July 2021, several experts expressed concern that achieving herd immunity may not be possible because Delta can transmit among vaccinated individuals.^[186] CDC published data showing that vaccinated people could transmit Delta, something officials believed was less likely with other variants. Consequently, WHO and CDC encouraged vaccinated people to continue with non-pharmaceutical interventions such as masking, social distancing, and quarantining if exposed.^[187]

History

2019

The

A pneumonia cluster was observed on 26 December and treated by Chinese pulmonologist Zhang Jixian. She informed the Wuhan Jianghan CDC on 27 December.^[189] After analyzing pneumonia patient samples, a genetic sequencing company named Vision Medicals reported the discovery of a novel coronavirus to the China CDC (CCDC) on 28 December.^[190][191]

On 30 December, a test report from CapitalBio Medlab addressed to Wuhan Central Hospital reported an erroneous positive result for SARS, causing doctors there to alert authorities. Eight of those doctors, including Li Wenliang (who was also punished on 3 January), were later admonished by the police for spreading false rumours. Director of the Emergency Department at the Central Hospital of Wuhan, Ai Fen, was also reprimanded.^[192][193] That evening, Wuhan Municipal Health Commission (WMHC) issued a notice about "the treatment of pneumonia of unknown cause".^[194] The next day, WMHC made the announcement public, confirming 27 cases^[195][196]—enough to trigger an investigation.^[197]

On 31 December, the WHO office in China was notified about the cluster of unknown pneumonia cases^[198][195] and immediately launched an investigation.^[197]

Official Chinese sources claimed that the early cases were mostly linked to the Huanan Seafood Wholesale Market, which also sold live animals.^[199] In May 2020, CCDC director George Gao initially ruled out the market as a possible origin, as animal samples collected there had tested negative.^[200]

2020

On 11 January, WHO was notified by the Chinese National Health Commission that the outbreak was associated with exposures in the market, and that China had identified a new type of coronavirus, which it isolated on 7 January.^[198]

Initially, the number of cases doubled approximately every seven and a half days.^[201] In early and mid-January, the virus spread to other Chinese provinces, helped by the Chinese New Year migration. Wuhan was a transport hub and major rail interchange.^[202] On 10 January, the virus' genome was shared publicly.^[203] A retrospective study published in March found that 6,174 people had reported symptoms by 20 January.^[204] A 24 January report indicated human transmission was likely occurring, and recommended personal protective equipment for health workers. It also advocated testing, given the outbreak's "pandemic potential".^[37][205] On 31 January, the first published modelling study warned of inevitable "independent self-sustaining outbreaks in major cities globally" and called for "large-scale public health interventions."^[206]

On 30 January, 7,818 infections had been confirmed, leading WHO to declare the outbreak a

By 31 January, Italy indicated its first confirmed infections had occurred, in two tourists from China.[213] On 19 March, Italy overtook China as the country with the most reported deaths.^[214] By 26 March, the United States had overtaken China and Italy as the country with the highest number of confirmed infections.^[215] Genomic analysis indicated that the majority of New York's confirmed infections came from Europe, rather than directly from Asia.^[216] Testing of prior samples revealed a person who was infected in France on 27 December 2019^[217][218] and a person in the United States who died from the disease on 6 February.^[219]

In October, WHO reported that one in ten people around the world may have been infected, or 780 million people, while only 35 million infections had been confirmed.^[220]

On 9 November, Pfizer released trial results for a candidate vaccine, showing a 90 percent effectiveness in preventing infection. That day, Novavax submitted an FDA Fast Track application for their vaccine.^[221][222]

On 14 December,

On 4 February 2020, US Secretary of Health and Human Services Alex Azar waived liability for vaccine manufacturers in all cases except those involving "willful misconduct".^[225][226]

2021

On 2 January, the

On 12 March, several countries stopped using the

On 10 November, Germany advised against the Moderna vaccine for people under 30, due to a possible association with myocarditis.^[235] On 24 November, the Omicron variant was detected in South Africa; a few days later the World Health Organization declared it a VoC (variant of concern).^[236] The new variant is more infectious than the Delta variant.^[237]

2022

On 1 January, Europe passed 100 million cases amidst a surge in the Omicron variant.^[238] Later that month, the WHO recommended the rheumatoid arthritis drug Baricitinib for severe or critical patients. It also recommended the monoclonal antibody Sotrovimab in patients with non-severe disease, but only those who are at highest risk of hospitalization.^[239]

On 24 January, the

On 21 October, the United States surpassed 99 million cases of COVID-19, the most cases of any country.[246] By 30 October, the worldwide daily death toll was 424, the lowest since 385 deaths were reported on 12 March 2020.^[247] 17 November marked the three-year anniversary since health officials in China first detected COVID-19.^[248]

On 11 November, the WHO reported that deaths since the month of February had dropped 90 percent. Director-General Tedros said this was "cause for optimism".^[249] On 3 December, the WHO indicated that, "at least 90% of the world's population has some level of immunity to Sars-CoV-2".^[250] In early December, China began lifting some of its most stringent lockdown measures. Subsequent data from China's health authorities revealed that 248 million people, nearly 18 percent of its population, had been infected in the first 20 days of that month.^[251] On 29 December, the US joined Italy, Japan, Taiwan and India in requiring negative COVID-19 test results from all people traveling from China due to the new surge in cases. The EU refused similar measures, stating that the BF7 omicron variant had already spread throughout Europe without becoming dominant.^[252][253]

2023

On 4 January 2023, the World Health Organization said the information shared by China during the recent surge in infections lacked data, such as hospitalization rates.^[254] On 10 January, the WHO’s Europe office said the recent viral surge in China posed "no immediate threat."^[255] On 16 January, the WHO recommended that China monitor excess mortality to provide "a more comprehensive understanding of the impact of COVID-19."^[256]

On 30 January, the three-year anniversary of the original declaration, the World Health Organization determined that COVID-19 still met the criteria for a public health emergency of international concern (PHEIC).^[257]

On 19 March, WHO Director-General Tedros indicated he was "confident" the COVID-19 pandemic would cease to be a public health emergency by the end of the year.^[258] On 5 May, the WHO downgraded COVID-19 from being a global health emergency, though it continued to refer to it as a pandemic.^[259] The WHO does not make official declarations of when pandemics end.^[260][261] The decision came after Tedros convened with the International Health Regulations Emergency Committee, wherein the Committee noted that due to the decrease in deaths and hospitalisations, and the prevalence of vaccinations and the level of general immunity, it was time to remove the emergency designation and "transition to long-term management".^[262] Tedros agreed, reducing the classification to an "established and ongoing health issue".^[262]

By May 2023, most countries had returned to daily life as it was before the pandemic.^[263][264]

Responses

National reactions ranged from strict lockdowns to public education campaigns.^[265] WHO recommended that curfews and lockdowns should be short-term measures to reorganise, regroup, rebalance resources, and protect the health care system.^[266] As of 26 March 2020, 1.7 billion people worldwide were under some form of lockdown.^[267] This increased to 3.9 billion people by the first week of April—more than half the world's population.^[268][269]

In several countries, protests rose against restrictions such as lockdowns. A February 2021 study found that protests against restrictions were likely to directly increase the spread of the virus.^[270]

Asia

As of the end of 2021, Asia's peak had come at the same time and at the same level as the world as a whole, in May 2021.^[271] However, cumulatively they had experienced only half of the global average in cases.^[272]

China opted for containment, instituting strict lockdowns to eliminate viral spread.[273]^[274] The vaccines distributed in China included the BIBP, WIBP, and CoronaVac.^[275] It was reported on 11 December 2021, that China had vaccinated 1.162 billion of its citizens, or 82.5% of the total population of the country against COVID-19.^[276] China's large-scale adoption of zero-COVID had largely contained the first waves of infections of the disease.^{[277][278][279]} When the waves of infections due to the Omicron variant followed, China was almost alone in pursuing the strategy of zero-Covid to combat the spread of the virus in 2022.^[280] Lockdown continued to be employed in November to combat a new wave of cases;^[281][282] however, protests erupted in cities across China over the country's stringent measures,^[283][284] and in December that year, the country relaxed its zero-COVID policy.^[285] On 20 December 2022, the Chinese State Council narrowed its definition of what would be counted as a COVID-19 death to include solely respiratory failure, which led to skepticism by health experts of the government's total death count^[286][287] at a time when hospitals reported being overwhelmed with cases following the abrupt discontinuation of zero-COVID.^[288]

The first case in India was reported on 30 January 2020. India ordered a nationwide lockdown starting 24 March 2020,^[289] with a phased unlock beginning 1 June 2020. Six cities accounted for around half of reported cases—Mumbai, Delhi, Ahmedabad, Chennai, Pune and Kolkata.^[290] Post-lockdown, the Government of India introduced a contact tracking app called Aarogya Setu to help authorities manage contact tracing and vaccine distribution.^[291] India's vaccination program was considered to be the world's largest and most successful with over 90% of citizens getting the first dose and another 65% getting the second dose.^[292][293] A second wave hit India in April 2021, straining healthcare services.^[294] On 21 October 2021, it was reported that the country had surpassed 1 billion vaccinations.^[295]

Iran reported its first confirmed cases on 19 February 2020, in Qom.^[297][298] Early measures included the cancellation/closure of concerts and other cultural events,^[299] Friday prayers,^[300] and school and university campuses.^[301] Iran became a centre of the pandemic in February 2020.^[302][303] More than ten countries had traced their outbreaks to Iran by 28 February, indicating a more severe outbreak than the 388 reported cases.^[303][304] The Iranian Parliament closed, after 23 of its 290 members tested positive on 3 March 2020.^[305] At least twelve sitting or former Iranian politicians and government officials had died by 17 March 2020.^[306] By August 2021, the pandemic's fifth wave peaked, with more than 400 deaths in 1 day.^[307]

COVID-19 was confirmed in South Korea on 20 January 2020. Military bases were quarantined after tests showed three infected soldiers.^[308] South Korea introduced what was then considered the world's largest and best-organised screening programme, isolating infected people, and tracing and quarantining contacts.^[309] Screening methods included mandatory self-reporting by new international arrivals through mobile application,^[310] combined with drive-through testing,^[311] and increasing testing capability to 20,000 people/day.^[312] Despite some early criticisms,^[313] South Korea's programme was considered a success in controlling the outbreak without quarantining entire cities.^{[309][314][315]}

Europe

The COVID-19 pandemic arrived in Europe with its first confirmed case in Bordeaux, France, on 24 January 2020, and subsequently spread widely across the continent. By 17 March 2020, every country in Europe had confirmed a case,^[316] and all had reported at least one death, with the exception of Vatican City. Italy was the first European nation to experience a major outbreak in early 2020, becoming the first country worldwide to introduce a national lockdown.^[317] By 13 March 2020, the World Health Organization (WHO) declared Europe the epicentre of the pandemic^[318][319] and it remained so until the WHO announced it had been overtaken by South America on 22 May.^[320] By 18 March 2020, more than 250 million people were in lockdown in Europe.^[321] Despite deployment of COVID-19 vaccines, Europe became the pandemic's epicentre once again in late 2021.^[322][323]

The Italian outbreak began on 31 January 2020, when two Chinese tourists tested positive for SARS-CoV-2 in Rome.^[213] Cases began to rise sharply, which prompted the government to suspend flights to and from China and declare a state of emergency.^[324] On 22 February 2020, the Council of Ministers announced a new decree-law to contain the outbreak, which quarantined more than 50,000 people in northern Italy.^[325] On 4 March, the Italian government ordered schools and universities closed as Italy reached a hundred deaths. Sport was suspended completely for at least one month.^[326] On 11 March, Italian Prime Minister Giuseppe Conte closed down nearly all commercial activity except supermarkets and pharmacies.^[327][328] On 19 April, the first wave ebbed, as 7-day deaths declined to 433.^[329] On 13 October, the Italian government again issued restrictive rules to contain the second wave.^[330] On 10 November, Italy surpassed 1 million confirmed infections.^[331] On 23 November, it was reported that the second wave of the virus had led some hospitals to stop accepting patients.^[332]

The virus was first confirmed to have spread to Spain on 31 January 2020, when a German tourist tested positive for SARS-CoV-2 on

Devolution in the United Kingdom meant that each of its four countries developed its own response. England's restrictions were shorter-lived than the others.^[345] The UK government started enforcing social distancing and quarantine measures on 18 March 2020.^[346][347] On 16 March, Prime Minister Boris Johnson advised against non-essential travel and social contact, praising work from home and avoiding venues such as pubs, restaurants, and theatres.^[348][349] On 20 March, the government ordered all leisure establishments to close,^[350] and promised to prevent unemployment.^[351] On 23 March, Johnson banned gatherings and restricted non-essential travel and outdoor activity. Unlike previous measures, these restrictions were enforceable by police through fines and dispersal of gatherings. Most non-essential businesses were ordered to close.^[352] On 24 April 2020, it was reported that a promising vaccine trial had begun in England; the government pledged more than £50 million towards research.^[353] On 16 April 2020, it was reported that the UK would have first access to the Oxford vaccine, due to a prior contract; should the trial be successful, some 30 million doses would be available.^[354] On 2 December 2020, the UK became the first developed country to approve the Pfizer vaccine; 800,000 doses were immediately available for use.^[355] In August 2022 it was reported that viral infection cases had declined in the UK.^[356]

North America

The virus arrived in the United States on 13 January 2020.^[357] Cases were reported in all North American countries after Saint Kitts and Nevis confirmed a case on 25 March, and in all North American territories after Bonaire confirmed a case on 16 April.^[358]

Per Our World in Data, 103,436,829[3] confirmed cases have been reported in the United States with 1,127,152^[3] deaths, the most of any country, and the nineteenth-highest per capita worldwide.^[359] COVID-19 is the deadliest pandemic in US history;^[360] it was the third-leading cause of death in the US in 2020, behind heart disease and cancer.^[361] From 2019 to 2020, US life expectancy dropped by 3 years for Hispanic Americans, 2.9 years for African Americans, and 1.2 years for white Americans.^[362] These effects have persisted as US deaths due to COVID-19 in 2021 exceeded those in 2020.^[363] In the United States, COVID-19 vaccines became available under emergency use in December 2020, beginning the national vaccination program. The first COVID-19 vaccine was officially approved by the Food and Drug Administration on 23 August 2021.^[364] By 18 November 2022, while cases in the U.S. had declined, COVID variants BQ.1/BQ.1.1 had become dominant in the country.^[365][366]

In March 2020, as cases of community transmission were confirmed across

The COVID-19 pandemic was confirmed to have reached South America on 26 February 2020, when Brazil confirmed a case in São Paulo.^[372] By 3 April, all countries and territories in South America had recorded at least one case.^[373] On 13 May 2020, it was reported that Latin America and the Caribbean had reported over 400,000 cases of COVID-19 infection with 23,091 deaths. On 22 May 2020, citing the rapid increase of infections in Brazil, the World Health Organization WHO declared South America the epicentre of the pandemic.^[374][375] As of 16 July 2021, South America had recorded 34,359,631 confirmed cases and 1,047,229 deaths from COVID-19. Due to a shortage of testing and medical facilities, it is believed that the outbreak is far larger than the official numbers show.^[376]

The virus was confirmed to have spread to Brazil on 25 February 2020,^[377] when a man from São Paulo who had traveled to Italy tested positive for the virus.^[378] The disease had spread to every federative unit of Brazil by 21 March. On 19 June 2020, the country reported its one millionth case and nearly 49,000 reported deaths.^[379][380] One estimate of under-reporting was 22.62% of total reported COVID-19 mortality in 2020.^{[381][382][383]} As of 27 September 2023, Brazil, with 37,717,062^[3] confirmed cases and 704,659^[3] deaths, has the third-highest number of confirmed cases and second-highest death toll from COVID-19 in the world, behind only those of the United States and India.^[384]

Africa

The COVID-19 pandemic was confirmed to have spread to Africa on 14 February 2020, with the first confirmed case announced in Egypt.^[385][386] The first confirmed case in sub-Saharan Africa was announced in Nigeria at the end of February 2020.^[387] Within three months, the virus had spread throughout the continent; Lesotho, the last African sovereign state to have remained free of the virus, reported its first case on 13 May 2020.^[388][389] By 26 May, it appeared that most African countries were experiencing community transmission, although testing capacity was limited.^[390] Most of the identified imported cases arrived from Europe and the United States rather than from China where the virus originated.^[391] Many preventive measures were implemented by different countries in Africa including travel restrictions, flight cancellations, and event cancellations.^[392] Despite fears, Africa reported lower death rates than other, more economically developed regions.^[393]

In early June 2021, Africa faced a third wave of COVID infections with cases rising in 14 countries.^[394] By 4 July the continent recorded more than 251,000 new COVID cases, a 20% increase from the prior week and a 12% increase from the January peak. More than sixteen African countries, including Malawi and Senegal, recorded an uptick in new cases.^[395] The World Health Organization labelled it Africa's 'Worst Pandemic Week Ever'.^[396] In October 2022, WHO reported that most countries on the African continent will miss the goal of 70 percent vaccination by the end of 2022.^[397]

Oceania

The COVID-19 pandemic was confirmed to have reached Oceania on 25 January 2020, with the first confirmed case reported in Melbourne, Australia.^[398][399] It has since spread elsewhere in the region.^[400][399] Australia and New Zealand were praised for their handling of the pandemic in comparison to other Western nations, with New Zealand and each state in Australia wiping out all community transmission of the virus several times even after re-introduction into the community.^{[401][402][403]}

As a result of the high transmissibility of the Delta variant, however, by August 2021, the Australian states of

On 9 September 2022 restrictions were significantly relaxed. The aircraft mask mandate was scrapped nationwide and daily reporting transitioned to weekly reporting.[412]^[413][414] On 14 September, COVID-19 disaster payment for isolating persons was extended for mandatory isolation.^[415] By 22 September, all states had ended mask mandates on public transport, including in Victoria, where the mandate had lasted for approximately 800 days.^[416] On 30 September 2022, all Australian leaders declared the emergency response finished and announced the end of isolation requirements. These changes were due in part to high levels of 'hybrid immunity' and low case numbers.^[417]

Antarctica

Due to its remoteness and sparse population, Antarctica was the last continent to have confirmed cases of COVID-19.^{[418][419][420]} The first cases were reported in December 2020, almost a year after the first cases of COVID-19 were detected in China. At least 36 people were infected in the first outbreak in 2020,^[421] with several other outbreaks taking place in 2021 and 2022.^[422]

United Nations

The United Nations Conference on Trade and Development (UNSC) was criticised for its slow response, especially regarding the UN's global ceasefire, which aimed to open up humanitarian access to conflict zones.^[423][424] The United Nations Security Council was criticized due to the inadequate manner in which it dealt with the COVID-19 pandemic, namely the poor ability to create international collaboration during this crisis.^[425][426]

On 23 March 2020, United Nations Secretary-General

On 29 September 2020, Guterres urged the International Monetary Fund to help certain countries via debt relief and also call for countries to increase contributions to develop vaccines.^[432]

WHO

The WHO spearheaded initiatives such as the COVID-19 Solidarity Response Fund to raise money for the pandemic response, the UN COVID-19 Supply Chain Task Force, and the solidarity trial for investigating potential treatment options for the disease. The COVAX program, co-led by the WHO, GAVI, and the Coalition for Epidemic Preparedness Innovations (CEPI), aimed to accelerate the development, manufacture, and distribution of COVID-19 vaccines, and to guarantee fair and equitable access across the world.^[433][434]

Restrictions

The pandemic shook the world's economy, with especially severe economic damage in the United States, Europe and Latin America.^[435][436] A consensus report by American intelligence agencies in April 2021 concluded, "Efforts to contain and manage the virus have reinforced nationalist trends globally, as some states turned inward to protect their citizens and sometimes cast blame on marginalized groups." COVID-19 inflamed partisanship and polarisation around the world as bitter arguments exploded over how to respond. International trade was disrupted amid the formation of no-entry enclaves.^[437]

Travel restrictions

The pandemic led many countries and regions to impose quarantines, entry bans, or other restrictions, either for citizens, recent travellers to affected areas,^[438] or for all travellers.^[439][440] Travel collapsed worldwide, damaging the travel sector. The effectiveness of travel restrictions was questioned as the virus spread across the world.^[441] One study found that travel restrictions only modestly affected the initial spread, unless combined with other infection prevention and control measures.^[442][443] Researchers concluded that "travel restrictions are most useful in the early and late phase of an epidemic" and "restrictions of travel from Wuhan unfortunately came too late".^[444] The European Union rejected the idea of suspending the Schengen free travel zone.^[445][446]

Repatriation of foreign citizens

Several countries repatriated their citizens and diplomatic staff from Wuhan and surrounding areas, primarily through charter flights. Canada, the United States, Japan, India, Sri Lanka, Australia, France, Argentina, Germany and Thailand were among the first to do so.^[447] Brazil and New Zealand evacuated their own nationals and others.^[448][449] On 14 March, South Africa repatriated 112 South Africans who tested negative, while four who showed symptoms were left behind.^[450] Pakistan declined to evacuate its citizens.^[451]

On 15 February, the US announced it would evacuate Americans aboard the

Economics

The pandemic and responses to it damaged the global economy. On 27 February 2020, worries about the outbreak crushed US stock indexes, which posted their sharpest falls since 2008.[457]

Tourism collapsed due to travel restrictions, closing of public places including travel attractions, and advice of governments against travel. Airlines cancelled flights, while British regional airline Flybe collapsed.^[458] The cruise line industry was hard hit,^[459] and train stations and ferry ports closed.^[460] International mail stopped or was delayed.^[461]

The retail sector faced reductions in store hours or closures.^[462] Retailers in Europe and Latin America faced traffic declines of 40 percent. North America and Middle East retailers saw a 50–60 percent drop.^[463] Shopping centres faced a 33–43 percent drop in foot traffic in March compared to February. Mall operators around the world coped by increasing sanitation, installing thermal scanners to check the temperature of shoppers, and cancelling events.^[464]

Hundreds of millions of jobs were lost,^[465][466] including more than 40 million jobs in the US.^[467] According to a report by Yelp, about 60% of US businesses that closed will stay shut permanently.^[468] The International Labour Organization (ILO) reported that the income generated in the first nine months of 2020 from work across the world dropped by 10.7 percent, or $3.5 trillion.^[469]

Supply shortages

Pandemic fears led to panic buying, emptying groceries of essentials such as food, toilet paper, and bottled water. Panic buying stemmed from perceived threat, perceived scarcity, fear of the unknown, coping behaviour and social psychological factors (e.g. social influence and trust).^[470]

Supply shortages were due to disruption to factory and logistic operations; shortages were worsened by supply chain disruptions from factory and port shutdowns, and labour shortages.^[471]

Shortages continued as managers underestimated the speed of economic recovery after the initial economic crash. The technology industry, in particular, warned of delays from underestimates of semiconductor demand for vehicles and other products.^[472]

According to WHO Secretary-General Tedros Ghebreyesus, demand for personal protective equipment (PPE) rose one hundredfold, pushing prices up twentyfold.^[473][474] PPE stocks were exhausted everywhere.^{[475][476][477]}

In September 2021, the World Bank reported that food prices remained generally stable and the supply outlook remained positive. However, the poorest countries witnessed a sharp increase in food prices, reaching the highest level since the pandemic began.^[478][479] The Agricultural Commodity Price Index stabilized in the third quarter but remained 17% higher than in January 2021.^[480][479]

By contrast, petroleum products were in surplus at the beginning of the pandemic, as demand for gasoline and other products collapsed due to reduced commuting and other trips.

The performing arts and

The pandemic affected political systems, causing suspensions of legislative activities,^[492] isolations or deaths of politicians,^[493] and rescheduled elections.^[494] Although they developed broad support among epidemiologists, NPIs (non-pharmaceutical interventions) were controversial in many countries. Intellectual opposition came primarily from other fields, along with heterodox epidemiologists.^[495]

Brazil

The pandemic (and the

Multiple provincial-level administrators of the

In early March 2020, the Italian government criticised the EU's lack of solidarity with Italy.^{[516][517][518]} On 22 March 2020, after a phone call with Italian Prime Minister Giuseppe Conte, Russian President Vladimir Putin ordered the Russian army to send military medics, disinfection vehicles, and other medical equipment to Italy.^[519][520] In early April, Norway and EU states like Romania and Austria started to offer help by sending medical personnel and disinfectant,^[521] and European Commission President Ursula von der Leyen offered an official apology to the country .^[522]

United States

Beginning in mid-April 2020, protestors objected to government-imposed business closures and restrictions on personal movement and assembly.

There were also protest in regards to vaccine mandates in the United States.[532] In January 2022, the US Supreme Court struck down an OSHA rule that mandated vaccination or a testing regimen for all companies with greater than 100 employees.^[533][534]

Other countries

The number of journalists imprisoned or detained increased worldwide; some detentions were related to the pandemic.^[535][536] The planned NATO "Defender 2020" military exercise in Germany, Poland and the Baltic states, the largest NATO war exercise since the end of the Cold War, was held on a reduced scale.^[537][538]

The Iranian government was heavily affected by the virus, which infected some two dozen parliament members and political figures.

Diplomatic relations between Japan and South Korea worsened.^[542] South Korea criticised Japan's "ambiguous and passive quarantine efforts" after Japan announced travellers from South Korea must quarantine for two weeks.^[543] South Korean society was initially polarised on President Moon Jae-in's response to the crisis; many Koreans signed petitions calling for Moon's impeachment or praising his response.^[313]

Some countries passed emergency legislation. Some commentators expressed concern that it could allow governments to strengthen their grip on power.

The pandemic disrupted food systems worldwide,^[552][553] hitting at a time when hunger and undernourishment were rising- an estimated 690 million people lacked food security in 2019.^[554] Food access fell – driven by falling incomes, lost remittances, and disruptions to food production.^[555] In some cases, food prices rose.^[552][554] The pandemic and its accompanying lockdowns and travel restrictions slowed movement of food aid. According to the WHO, 811 million people were undernourished in 2020, "likely related to the fallout of COVID-19".^[556][436]

Education

The pandemic impacted educational systems in many countries. Many governments temporarily closed educational institutions, often replaced by

The pandemic impacted global health for many conditions. Hospital visits fell.^[560] Visits for heart attack symptoms declined by 38% in the US and 40% in Spain.^[561] The head of cardiology at the University of Arizona said, "My worry is some of these people are dying at home because they're too scared to go to the hospital."^[562] People with strokes and appendicitis were less likely to seek treatment.^{[563][564][562]} Medical supply shortages impacted many people.^[565] The pandemic impacted mental health,^[566][567] increasing anxiety, depression, and post-traumatic stress disorder, affecting healthcare workers, patients and quarantined individuals.^[568][569]

In late 2022, during the first northern hemisphere autumn and winter seasons following the widespread relaxation of global public health measures, North America and Europe experienced a surge in respiratory viruses and coinfections in both adults and children.

The pandemic and the reaction to it positively affected the

A wide variety of largely mammalian species, both captive and wild, have been shown to be susceptible to SARS-CoV-2, with some encountering particularly fatal outcomes.^[580] In particular, both farmed and wild mink have developed highly symptomatic and severe COVID-19 infections, with a mortality rate as high as 35–55% according to one study.^[581][582] White-tailed deer, on the other hand, have largely avoided severe outcomes but have effectively become natural reservoirs of the virus, with large numbers of free-ranging deer infected throughout the US and Canada, including approximately 80% of Iowa's wild deer herd.^[583][584] An August 2023 study appeared to confirm the status of white-tailed deer as a disease reservoir, noting that the viral evolution of SARS-CoV-2 in deer occurs at triple the rate of its evolution in humans and that infection rates remained high, even in areas rarely frequented by humans.^[585]

Discrimination and prejudice

Heightened prejudice,

Age-based discrimination against older adults increased during the pandemic. This was attributed to their perceived vulnerability and subsequent physical and social isolation measures, which, coupled with their reduced social activity, increased dependency on others. Similarly, limited digital literacy left the elderly more vulnerable to isolation, depression, and loneliness.^[598]

In a correspondence published in The Lancet in 2021, German epidemiologist Günter Kampf described the harmful effects of "inappropriate stigmatisation of unvaccinated people, who include our patients, colleagues, and other fellow citizens", noting the evidence that vaccinated individuals play a large role in transmission.^[599] American bioethicist Arthur Caplan responded to Kampf, writing "Criticising [the unvaccinated] who... wind up in hospitals and morgues in huge numbers, put stress on finite resources, and prolong the pandemic... is not stigmatising, it is deserved moral condemnation."^[600]

In January 2022, Amnesty International urged Italy to change their anti-COVID-19 restrictions to avoid discrimination against unvaccinated people, saying that "the government must continue to ensure that the entire population can enjoy its fundamental rights." The restrictions included mandatory vaccination over the age of 50, and mandatory vaccination to use public transport.^[601]

Lifestyle changes

The pandemic triggered massive changes in behaviour, from increased Internet commerce to cultural changes in the workplace. Online retailers in the US posted $791.70 billion in sales in 2020, an increase of 32.4% from $598.02 billion the year before.

Education in some countries temporarily shifted from physical attendance to video conferencing.[606] Massive layoffs shrank the airline, travel, hospitality, and other industries.^[607][608] Despite most corporations implementing measures to address COVID-19 in the workplace, a poll from Catalyst found that as many as 68% of employees around the world felt that these policies were only performative and "not genuine".^[609]

The pandemic led to a surge in

In some areas, religious groups exacerbated the spread of the virus, through large gatherings and the dissemination of misinformation.^{[626][627][628]} Some religious leaders decried what they saw as violations of religious freedom.^[629] In other cases, religious identity was a beneficial factor for health, increasing compliance with public health measures and protecting against the negative effects of isolation on mental wellbeing.^{[630][631][632]}

Information dissemination

Some news organizations removed their online paywalls for some or all of their pandemic-related articles and posts.^[633] Many scientific publishers provided pandemic-related journal articles to the public free of charge as part of the National Institutes of Health's COVID-19 Public Health Emergency Initiative.^{[634][635][636]} According to one estimate from researchers at the University of Rome, 89.5% of COVID-19-related papers were open access, compared to an average of 48.8% for the ten most deadly human diseases.^[637] The share of papers published on preprint servers prior to peer review increased dramatically.^[638]

Misinformation

The COVID-19 pandemic had a major impact on popular culture. It was included in the narratives of ongoing pre-pandemic television series and become a central narrative in new ones, with mixed results.^[642] Writing for The New York Times about the then-upcoming BBC sitcom Pandemonium on 16 December 2020, David Segal asked, "Are we ready to laugh about Covid-19? Or rather, is there anything amusing, or recognizable in a humorous way, about life during a plague, with all of its indignities and setbacks, not to mention its rituals and rules."^[643]

The pandemic had driven some people to seek peaceful escapism in media, while others were drawn towards fictional pandemics (e.g. zombie apocalypses) as an alternate form of escapism.^[644] Common themes have included contagion, isolation and loss of control.^[645] Many drew comparisons to the fictional film Contagion (2011),^[646][647] praising its accuracies while noting some differences,^[648] such as the lack of an orderly vaccine rollout.^[649][650]

As people turned to music to relieve emotions evoked by the pandemic, Spotify listenership showed that classical, ambient and children's genres grew, while pop, country and dance remained relatively stable.^[651][652]

Transition to later phases

On 5 May 2023, the WHO declared that the pandemic was no longer a public health emergency of international concern.^[653] This led several media outlets to incorrectly report that this meant the pandemic was "over". The WHO commented to Full Fact that it was unlikely to declare the pandemic over "in the near future" and mentioned cholera, which it considers to have continued to be a pandemic since 1961.^[654] The WHO does not have an official category for pandemics or make declarations of when pandemics start or end.^{[260][261][655]}

In June 2023, Hans Kluge, director of the WHO in Europe, commented that "While the international public health emergency may have ended, the pandemic certainly has not". The WHO in Europe launched a transition plan to manage the public health response to COVID-19 in the coming years and prepare for possible future emergencies.^[656]

Future endemic phase

In June 2022, an article in Human Genomics said that the pandemic was still "raging", but that "now is the time to explore the transition from the pandemic to the endemic phase."^[657]

A March 2022 review declared the transition to endemic status to be "inevitable".

In Australia, the pandemic caused an increase in occupational burnout in 2022.^[664]

During the pandemic, a large percentage of workers in Canada came to prefer working from home, which had an impact on the traditional work model. Some corporations made efforts to force workers to return to work on-site, while some embraced the idea.^[665]

Travel

There was a "travel boom" causing air travel to recover at rates faster than anticipated, and the aviation industry became profitable in 2023 for the first time since 2019, before the pandemic.^[666] However, economic issues meant some predicted that the boom would begin to slow down.^[667] Business travel on airlines was still below pre-pandemic levels and is predicted not to recover.^[668]

Health

An increase in excess deaths from underlying causes not related to COVID-19 has been largely blamed on systematic issues causing delays in health care and screening during the pandemic, which has resulted in an increase of non-COVID-19 related deaths.^[669]

Immunizations

During the pandemic, millions of children missed out on vaccinations as countries focused efforts on combating COVID-19. Efforts were made to increase vaccination rates among children in

• Coronavirus diseases
• Emerging infectious disease
• Globalization and disease
• List of epidemics and pandemics

Notes

References