CREB1

CREB1
Gene ontology
Molecular function	DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific cAMP response element binding transcription coregulator activity RNA polymerase II cis-regulatory region sequence-specific DNA binding enzyme binding protein binding double-stranded DNA binding DNA binding sequence-specific DNA binding identical protein binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription factor binding Hsp70 protein binding histone acetyltransferase binding arrestin family protein binding
Cellular component	mitochondrion nucleus ATF4-CREB1 transcription factor complex chromatin transcription regulator complex nucleoplasm axon mitochondrial matrix
Biological process	cellular response to nerve growth factor stimulus positive regulation of lipid biosynthetic process positive regulation of long-term synaptic potentiation rhythmic process cellular response to insulin-like growth factor stimulus transcription by RNA polymerase II response to organic substance mammary gland development protein phosphorylation type I pneumocyte differentiation circadian rhythm positive regulation of multicellular organism growth response to L-glutamate lung saccule development lung epithelium development transforming growth factor beta receptor signaling pathway regulation of apoptotic process cellular response to transforming growth factor beta stimulus response to glucagon regulation of transcription, DNA-templated negative regulation of transcription by competitive promoter binding response to nicotine positive regulation of osteoclast differentiation memory negative regulation of gene expression transcription, DNA-templated positive regulation of transcription, DNA-templated lactation positive regulation of transforming growth factor beta3 production viral process positive regulation of fat cell differentiation negative regulation of neuron death cell differentiation cellular response to hepatocyte growth factor stimulus protein stabilization cellular response to platelet-derived growth factor stimulus regulation of circadian rhythm secretory granule organization regulation of glial cell proliferation visual learning regulation of cell size pituitary gland development positive regulation of RNA polymerase II transcription preinitiation complex assembly response to hypoxia axonogenesis regulation of fibroblast proliferation cellular response to growth factor stimulus human ageing chemotaxis to arachidonic acid response to activity cellular response to zinc ion cellular response to fatty acid positive regulation of apoptotic process positive regulation of hormone secretion signal transduction positive regulation of transcription by RNA polymerase II positive regulation of cardiac muscle tissue development cellular response to leukemia inhibitory factor cellular response to retinoic acid
Sources:Amigo / QuickGO

Ensembl				ENSG00000118260	ENSMUSG00000025958
UniProt	P16220	Q01147
RefSeq (mRNA)	NM_004379 NM_134442 NM_001320793 NM_001371426 NM_001371427 NM_001371428	NM_001037726 NM_009952 NM_133828
RefSeq (protein)	NP_001307722 NP_004370 NP_604391 NP_001358355 NP_001358356 NP_001358357	NP_001032815 NP_034082 NP_598589
Location (UCSC)	Chr 2: 207.53 – 207.61 Mb	Chr 1: 64.57 – 64.64 Mb
PubMed search	[3]	[4]

Wikidata

View/Edit Human

View/Edit Mouse

CAMP responsive element binding protein 1, also known as CREB-1, is a

. The binding of CREB1 stimulates transcription.

This protein is a

See also

• CREB

Interactions

CREB1 has been shown to

with:

• CEBPB,^[8]
• CREB binding protein,^{[9][10][11][12][13][14][15][16][17][18]}
• FHL2,^[19]
• FHL3,^[19]
• FHL5.^[19]
• HTATIP,^[20]
• P53,^[15] and
• RPS6KA5.^[21][22]

References

Further reading

• Don J, Stelzer G (Feb 2002). "The expanding family of CREB/CREM transcription factors that are involved with spermatogenesis". Molecular and Cellular Endocrinology. 187 (1–2): 115–24.
  S2CID 23023082
  .
• Pandey SC (Oct 2004). "The gene transcription factor cyclic AMP-responsive element binding protein: role in positive and negative affective states of alcohol addiction". Pharmacology & Therapeutics. 104 (1): 47–58.
  PMID 15500908
  .
• Wu H, Zhou Y, Xiong ZQ (Jul 2007). "Transducer of regulated CREB and late phase long-term synaptic potentiation". The FEBS Journal. 274 (13): 3218–23.
  S2CID 15804067
  .
• Kitagawa K (Jul 2007). "CREB and cAMP response element-mediated gene expression in the ischemic brain". The FEBS Journal. 274 (13): 3210–7.
  S2CID 29917569
  .
• Takemori H, Kajimura J, Okamoto M (Jul 2007). "TORC-SIK cascade regulates CREB activity through the basic leucine zipper domain". The FEBS Journal. 274 (13): 3202–9.
  S2CID 30323449
  .
• Siu YT, Jin DY (Jul 2007). "CREB--a real culprit in oncogenesis". The FEBS Journal. 274 (13): 3224–32.
  S2CID 39040147
  .

External links

• CREB1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human CREB1 genome location and CREB1 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

• v
• t
• e