CXCL14
| chemokine (C-X-C motif) ligand 14 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | CXCL14 | ||||||
| Alt. symbols | SCYB14, BRAK, NJAC, bolekine, Kec, MIP-2g, BMAC, KS1 | ||||||
Chr. 5 q31 | |||||||
| |||||||
Chemokine (C-X-C motif) ligand 14 (CXCL14) is a small cytokine belonging to the CXC chemokine family that is also known as BRAK (for breast and kidney-expressed chemokine).[1] Mature CXCL14 has many of the conserved features of the CXC chemokine subfamily but has some differences too, such as a shorter N-terminus and five extra amino acids in the region between its third and fourth cysteines.[1] CXCL14 is constitutively expressed at high levels in many normal tissues, where its cellular source is thought to be fibroblasts.[2] However, it is reduced or absent from most
endothelial cell chemotaxis.[6] The gene for CXCL14 contains four exons and is located on chromosome 5 in humans.[1]
References