Calcium carbimide
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Calcium carbimide, sold as the
citrate salt under the trade name Temposil, is a disulfiram-like medication. Its effects are similar to the medication disulfiram (Antabuse) in that it interferes with the normal metabolism of alcohol by preventing the breakdown of the metabolic byproduct acetaldehyde
. The result is that when alcohol is consumed by users of calcium carbimide, they experience severe reactions which include symptoms such as sweating, difficulty breathing, rapid heartbeat, rash, nausea and vomiting, and headache.
A recent 9-year study found that incorporation of supervised carbimide and the similar medication, disulfiram, into a comprehensive treatment program resulted in an abstinence rate of over 50%.[1]
Temposil was developed by Drs. Ken Ferguson and Gordon Bell, who tested the medication on themselves.[2][3][4] It was patented in 1955 by the Alcoholism Research Foundation of Ontario.[5]
See also
References
- PMID 16433735.
- ^ "Ogspi "PLO" 2005 Obituary". Ontario Genealogical Society. Archived from the original on 2015-09-24. Retrieved 2014-03-11.
- ^ "Deaths - Canadian Medical Association Journal". CMAJ. 162 (8). Canadian Medical Association Journal: 1259. 18 April 2000.
- ^ "Pioneer in Addiction Treatment Dr. Robert Gordon Bell Leaves Behind a Legacy of Hope and Healing" (PDF). Ontario Federation of Community Mental Health and Addiction Programs. Archived from the original (PDF) on 2014-03-11.
- ISBN 9781896357836.
