Calcium channel opener
Source: Wikipedia, the free encyclopedia.
A calcium channel opener is a type of drug which facilitates ion transmission through calcium channels.
An example is
voltage-dependent calcium channels.[1]
In contrast to Bay K8644, which is not for clinical use, ambroxol is a frequently used mucolytic drug that triggers lysosomal secretion by mobilizing calcium from acidic calcium stores.[2] This effect does most likely not occur by a direct interaction between the drug and a lysosomal calcium channel, but indirectly by neutralizing the acidic pH within lysosomes. Calcium permeable ion channels in lysosomal membranes that may be activated by a luminal pH increase include two pore channels (TPCs), mucolipin TRP channels (TRPMLs) and purinergic receptors of the P2X channel type.[3][4]
See also
References
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VGKCsTooltip Voltage-gated potassium channels
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IRKsTooltip Inwardly rectifying potassium channel
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K2PsTooltip Tandem pore domain potassium channel
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VGSCsTooltip Voltage-gated sodium channels
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CaCCsTooltip Calcium-activated chloride channel
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TRPs Tooltip Transient receptor potential channels |
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LGICs Tooltip Ligand gated ion channels |
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