Carnitine-acylcarnitine translocase

Source: Wikipedia, the free encyclopedia.
SLC25A20
Identifiers
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Ensembl
UniProt
RefSeq (mRNA)

NM_000387

NM_020520

RefSeq (protein)

NP_000378

NP_065266

Location (UCSC)Chr 3: 48.86 – 48.9 MbChr 9: 108.54 – 108.56 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
solute carrier family 25 (carnitine/acylcarnitine translocase), member 20
Identifiers
SymbolSLC25A20
Alt. symbolsCACT
Chr. 3 p21.31
Search for
StructuresSwiss-model
DomainsInterPro

Carnitine-acylcarnitine translocase (CACT) is responsible for passive transport of carnitine and carnitine-fatty acid complexes and across the inner mitochondrial membrane as part of the carnitine shuttle system.

Function

Fatty acyl–carnitine can diffuse from the cytosol across the porous outer mitochondrial membrane to the intermembrane space, but must utilize CACT to cross the nonporous inner mitochondrial membrane and reach the mitochondrial matrix. CACT is a

intermembrane space as one molecule of fatty acyl–carnitine moves into the matrix.[5]

Clinical significance

A disorder is associated with carnitine-acylcarnitine translocase deficiency. This disorder disrupts the carnitine shuttle system from moving fatty acids across the mitochondrial membrane, leading to a decrease in fatty acid catabolism. The result is an accumulation of fatty acid within muscles and liver, decreased tolerance to long term exercise, inability to fast for more than a few hours, muscle weakness and wasting, and a strong acidic smell on the breath (due to protein catabolism).

Acyl-CoA from cytosol to the mitochondrial matrix

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000178537 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032602 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ISSN 1040-452X
    .