Cathine

Source: Wikipedia, the free encyclopedia.
D-norpseudoephedrine
Clinical data
Other names
  • (+)-norpseudoephedrine
  • Cathine
Routes of
administration
Oral
Drug class
  • Appetite suppressant
  • CNS stimulant
ATC code
Legal status
Legal status
Pharmacokinetic data
Elimination half-life1.8–8.6 hours[2]
Identifiers
  • (1S,2S)-2-amino-1-phenylpropan-1-ol
JSmol)
Solubility in water20 mg/mL (20 °C)
  • O[C@@H](c1ccccc1)[C@@H](N)C
  • InChI=1S/C9H13NO/c1-7(10)9(11)8-5-3-2-4-6-8/h2-7,9,11H,10H2,1H3/t7-,9+/m0/s1 checkY
  • Key:DLNKOYKMWOXYQA-IONNQARKSA-N checkY
 ☒NcheckY (what is this?)  (verify)

D-norpseudoephedrine, also known as cathine and (+)-norpseudoephedrine, is a

Catha edulis (khat), and contributes to its overall effects.[3] It has approximately 7-10% the potency of amphetamine.[3]

Pharmacology

Like amphetamines, cathinone and ephedrine, cathine acts as a norepinephrine releasing agent (NRA).[3] It also acts as a dopamine releasing agent (DRA).[3][4]

Chemistry

Cathine is one of the four stereoisomers of phenylpropanolamine (PPA).

Regulation

The

milliliter in urine. Cathine is a Schedule III drug under the Convention on Psychotropic Substances.[5] In the United States, it is classified as a Schedule IV controlled substance.[6]

In Australia, Cathine is officially a schedule 4 drug prescription only, but is not available or approved for any medical use.

Catha edulis
).

In Hong Kong, cathine is regulated under Schedule 1 of Hong Kong's Chapter 134 Dangerous Drugs Ordinance. Unlawful possession is punishable by severe fines and imprisonment.

Pregnancy

association to women not using ephedra (odds ratio 2.8, confidence interval 1.0–7.3).[7]

A small study of 642 participants in Yemen found that among pregnant women who chewed khat (containing D-norpseudoephedrine) there was no increased risk of

See also

References

  1. ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
  2. PMID 12848785
    .
  3. ^ .
  4. .
  5. ^ "List of psychotropic substances under international control" (PDF). International Narcotics Control Board. Archived from the original (PDF) on 2012-08-31.
  6. ^ "Scheduling Actions" (PDF). Diversion Control Division. U.S. Department Of Justice, Drug Enforcement Administration (DEA).
  7. PMID 30601144
    .
  8. .
  9. .