Ceragenin
 | This article needs to be updated. (January 2014) |
Ceragenins, or cationic steroid antimicrobials (CSAs), are synthetically-produced, small-molecule chemical compounds consisting of a
Ceragenins were discovered by Paul B. Savage of Brigham Young University's Department of Chemistry and Biochemistry. In data previously presented by Savage and other researchers, CSAs were shown to have broad-spectrum antibacterial activity.[3] Derya Unutmaz, Associate Professor of Microbiology and Immunology at the Vanderbilt University School of Medicine, tested several CSAs in his laboratory for their ability to kill HIV directly. Unutmaz said in 2006 "We have some preliminary but very exciting results. But we would like to formally show this before making any claims that would cause unwanted hype."[4]
On February 6, 2006, researchers including Savage announced, before peer review, that a ceragenin compound, CSA-54, appeared to inactivate HIV.[2][5]
References
- PMID 15493921.
- ^ a b "Vanderbilt University, Brigham Young University, and Ceragenix Pharmaceuticals Report Novel Drug Compound Kills Multiple HIV Strains; Synthetic Small Molecule Acts Through Unique Strain-Independent Virucidal Mechanism" (Press release). Ceragenix Pharmaceuticals. 2006-02-06. Archived from the original on 2006-05-23.
- PMID 5638.
- ^ "Chemical 'blocks HIV infection'". BBC News Online. 2006-02-09.
- ^ Mims, Bob (2006-02-07). "Has BYU prof found AIDS cure?". The Salt Lake Tribune. Archived from the original on 2006-04-07.
External links
- Mitchell, Gabriel; Silvis, Melanie R.; Talkington, Kelsey C.; Budzik, Jonathan M.; Dodd, Claire E.; Paluba, Justin M.; Oki, Erika A.; Trotta, Kristine L.; Licht, Daniel J.; Jimenez-Morales, David; Chou, Seemay; Savage, Paul B.; Gross, Carol A.; Marletta, Michael A.; Cox, Jeffery S. (22 February 2022). "Ceragenins and Antimicrobial Peptides Kill Bacteria through Distinct Mechanisms". mBio. 13 (1). American Society for Microbiology: e0272621. PMID 35073755.
- Wnorowska, Urszula; Piktel, Ewelina; Deptuła, Piotr; Wollny, Tomasz; Król, Grzegorz; Głuszek, Katarzyna; Durnaś, Bonita; Pogoda, Katarzyna; Savage, Paul B.; Bucki, Robert (10 November 2022). "Ceragenin CSA-13 displays high antibacterial efficiency in a mouse model of urinary tract infection". Scientific Reports. 12 (1): 19164. PMID 36357517.