Varicella vaccine

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Chickenpox vaccine
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Not to be confused with
Variola vaccine
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Varicella vaccine
Varicella
Vaccine typeAttenuated
Clinical data
Trade namesVarivax, Varilrix, others
AHFS/Drugs.comMonograph
MedlinePlusa607029
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Pregnancy
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subcutaneous
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Varicella vaccine, also known as chickenpox vaccine, is a

injection just under the skin.[10] Another vaccine, known as zoster vaccine, is used to prevent diseases caused by the same virus – the varicella zoster virus.[11]

The World Health Organization (WHO) recommends routine vaccination only if a country can keep more than 80% of people vaccinated.[10] If only 20% to 80% of people are vaccinated it is possible that more people will get the disease at an older age and outcomes overall may worsen.[10] Either one or two doses of the vaccine is recommended.[10] In the United States two doses are recommended starting at twelve to fifteen months of age.[9] As of 2017, twenty-three countries recommend all non-medically exempt children receive the vaccine, nine recommend it only for high risk groups, three additional countries recommend use in only parts of the country, while other countries make no recommendation.[12] Not all countries provide the vaccine due to its cost.[13] In the United Kingdom, Varilrix, a live viral vaccine[14] is approved from the age of 12 months, but only recommended for certain at risk groups.

Minor side effects may include pain at the site of injection, fever, and rash.

weakened virus.[9]

A live attenuated varicella vaccine, the Oka strain, was developed by Michiaki Takahashi and his colleagues in Japan in the early 1970s.[15] American vaccinologist Maurice Hilleman's team developed a chickenpox vaccine in the United States in 1981, based on the "Oka strain" of the varicella virus.[16][17][18] The chickenpox vaccine first became commercially available in 1984.[10] It is on the WHO Model List of Essential Medicines.[19][20]

Medical uses

Varicella vaccine is 70% to 90% effective for preventing varicella and more than 95% effective for preventing severe varicella.[21] Follow-up evaluations have taken place in the United States of children immunized that revealed protection for at least 11 years. Studies were conducted in Japan which indicated protection for at least 20 years.[21]

People who do not develop enough protection when they get the vaccine may develop a mild case of the disease when in close contact with a person with chickenpox. In these cases, people show very little sign of illness.[22] This has been the case of children who get the vaccine in their early childhood and later have contact with children with chickenpox. Some of these children may develop a mild chickenpox also known as breakthrough disease.[23]

Another vaccine, known as

shingles (also called herpes zoster) and postherpetic neuralgia, which are caused by the same virus.[11] The recombinant zoster (shingles) vaccine is recommended for adults aged 50 years and older.[24]

Duration of immunity

The long-term duration of protection from varicella vaccine is unknown, but there are now persons vaccinated twenty years ago with no evidence of waning immunity, while others have become vulnerable in as few as six years. Assessments of duration of immunity are complicated in an environment where natural disease is still common, which typically leads to an overestimation of effectiveness.[25]

Some vaccinated children have been found to lose their protective antibody in as little as five to eight years.[26] However, according to the World Health Organization (WHO): "After observation of study populations for periods of up to 20 years in Japan and 10 years in the United States, more than 90% of immunocompetent persons who were vaccinated as children were still protected from varicella." However, since only one out of five Japanese children were vaccinated, the annual exposure of these vaccinees to children with natural chickenpox boosted the vaccinees' immune system. In the United States, where universal varicella vaccination has been practiced, the majority of children no longer receive exogenous (outside) boosting, thus, their cell-mediated immunity to VZV (varicella zoster virus) wanes – necessitating booster chickenpox vaccinations.[27] As time goes on, boosters may be necessary. Persons exposed to the virus after vaccination tend to experience milder cases of chickenpox if they develop the disease.[28]

Catching "wild" chickenpox as a child has been thought to commonly result in lifelong immunity. Indeed, parents have deliberately ensured this in the past with "

better source needed] The US Centers for Disease Control and Prevention (CDC) and corresponding national organizations are carefully observing the failure rate which may be high compared with other modern vaccines – large outbreaks of chickenpox having occurred at schools which required their children to be vaccinated.[30]

Chickenpox

Prior to the widespread introduction of the vaccine in the United States in 1995 (1986 in Japan and 1988 in Korea[31]), there were around 4,000,000 cases per year in the United States, mostly in children, with typically 10,500–13,000 hospital admissions (range, 8,000–18,000), and 100–150 deaths each year.[31][27][10][32] Most of the deaths were among young children.[33]

During 2003, and the first half of 2004, the CDC reported eight deaths from varicella, six of whom were children or adolescents. These deaths and hospital admissions have substantially declined in the US due to vaccination,[34][35] though the rate of shingles infection has increased as adults are less exposed to infected children (which would otherwise help protect against shingles).[36][37][38] Ten years after the vaccine was recommended in the US, the CDC reported as much as a 90% drop in chickenpox cases, a varicella-related hospital admission decline of 71%[32] and a 97% drop in chickenpox deaths among those under 20.[39]

Vaccines are less effective among high-risk patients, as well as being more dangerous because they contain attenuated live virus. In a study performed on children with an impaired immune system, 30% had lost the antibody after five years, and 8% had already caught wild chickenpox in that five-year period.[40]

Herpes zoster

Herpes zoster (shingles) most often occurs in the elderly and is only rarely seen in children. The incidence of herpes zoster in vaccinated adults is 0.9/1000 person-years, and is 0.33/1000 person-years in vaccinated children; this is lower than the overall incidence of 3.2–4.2/1000 person-years.[41][42]

The risk of developing shingles is reduced for children who receive the varicella vaccine, but not eliminated.[43] The CDC stated in 2014: "Chickenpox vaccines contain weakened live VZV, which may cause latent (dormant) infection. The vaccine-strain VZV can reactivate later in life and cause shingles. However, the risk of getting shingles from vaccine-strain VZV after chickenpox vaccination is much lower than getting shingles after natural infection with wild-type VZV."[44]

The risk of shingles is significantly lower among children who have received varicella vaccination, including those who are immunocompromised. The risk of shingles is approximately 80% lower among healthy vaccinated children compared to unvaccinated children who had wild-type varicella.[43][45] A population with high varicella vaccination also has lower incidence of shingles in unvaccinated children, due to herd immunity.[45]

Schedule

The WHO recommends one or two doses with the initial dose given at 12 to 18 months of age.[10] The second dose, if given, should occur at least one to three months later.[10] The second dose, if given, provides the additional benefit of improved protection against all varicella.[46] This vaccine is a shot given subcutaneously (under the skin). It is recommended for all children under 13 and for everyone 13 or older who has never had chickenpox.[47]

In the United States, two doses are recommended by the CDC. For a routine vaccination, the first dose is administered at 12 to 15 months of age and a second dose at age 4–6 years. However, the second dose can be given as early as 3 months after the first dose. If an individual misses the timing for the routine vaccination, the individual is eligible to receive a catch-up vaccination. For a catch-up vaccination, individuals between 7 and 12 years old should receive a two-dose series 3 months apart (a minimum interval of 4 weeks). For individuals 13–18 years old, the catch-up vaccination should be given 4 to 8 weeks apart (a minimum interval of 4 weeks).[48] The varicella vaccine did not become widely available in the United States until 1995.[49]

In the UK, the vaccine is only available on the National Health Service for those who are in close contact with someone who is particularly vulnerable to chickenpox.[50] As there is an increased risk of shingles in adults due to possible lack of contact with chickenpox-infected children providing a natural boosting to immunity, and the fact that chickenpox is usually a mild illness, the NHS cites concerns about unvaccinated children catching chickenpox as adults when it is more dangerous.[50] However, the vaccine is approved for 12 months and up and is available privately, with a second dose to be given a year after the first.[14]

Contraindications

The varicella vaccine is not recommended for seriously ill people,

transfusions during the past five months.[51][52] Additionally, the varicella vaccine is not recommended for people who are taking salicylates (e.g. aspirin).[52] After receiving the varicella vaccine, the use of salicylates should be avoided for at least six weeks.[52] The varicella vaccine is also not recommended for individuals who have received a live vaccine in the last four weeks,[52] because live vaccines that are administered too soon within one another may not be as effective.[52] It may be usable in people with HIV infections who have a good blood count and are receiving appropriate treatment.[10] Specific antiviral medication, such as acyclovir, famciclovir, or valacyclovir, are not recommended 24 hours before and 14 days after vaccination.[53]

Side effects

Serious side effects are very rare. From 1998 to 2013, only one vaccine-related death was reported: an English child with pre-existent leukemia. On some occasions, severe reactions such as meningitis and pneumonia have been reported (mainly in inadvertently vaccinated immunocompromised children) as well as anaphylaxis.[41]

The possible mild side effects include redness,

soreness at the injection site, as well as fever. A few people may develop a mild rash, which usually appears around the injection site.[54]

There is a short-term risk of developing

herpes zoster (shingles) following vaccination. However, this risk is less than the risk due to a natural infection resulting in chickenpox.[55]: 378  Most of the cases reported have been mild and have not been associated with serious complications.[56]

Approximately 5% of children who receive the vaccine develop a fever or rash. Adverse reaction reports for the period 1995 to 2005 found no deaths attributed to the vaccine despite approximately 55.7 million doses being delivered.[57] Cases of vaccine-related chickenpox have been reported in patients with a weakened immune system,[58][59] but no deaths.

The literature contains several reports of adverse reactions following varicella vaccination, including vaccine-strain zoster in children and adults.[60]

History

The varicella zoster vaccine is made from the Oka/

GlaxoSmithKline.[61] American vaccinologist Maurice Hilleman's team at Merck then used the Oka strain to prepare a chickenpox vaccine in 1981.[16][17][18]

Japan was among the first countries to vaccinate for chickenpox. The vaccine developed by Hilleman was first licensed in the United States in 1995.[16][62] Routine vaccination against varicella zoster virus is also performed in the United States, and the incidence of chickenpox has been dramatically reduced there (from four million cases per year in the pre-vaccine era to approximately 390,000 cases per year as of 2014).[63]

As of 2019, standalone varicella vaccines are available in all 27

fevers leading to seizures after the first dose of the MMRV vaccine.[64] "Countries that implemented UVV experienced decreases in varicella incidence, hospitalizations and complications, showing overall beneficial impact."[64]

Varicella vaccination is recommended in Canada for all healthy children aged 1 to 12, as well as susceptible adolescents and adults 50 years of age and younger; "may be considered for people with select

acetylsalicylic acid [ASA])," and others.[65]

Australia has adopted recommendations for routine immunization of children and susceptible adults against chickenpox.[66]

Other countries, such as the United Kingdom, have targeted recommendations for the vaccine, e.g., for susceptible health care workers at risk of varicella exposure. In the UK, varicella antibodies are measured as part of the routine of prenatal care, and by 2005 all National Health Service personnel had determined their immunity and been immunized if they were non-immune and have direct patient contact. Population-based immunization against varicella is not otherwise practised in the UK.[67]

Since 2013, the MMRV vaccine is offered for free to all Brazilian citizens.[68]

Society and culture

Catholic Church

Main article: Use of fetal tissue in vaccine development § Position of the Catholic Church

The

Congregation for the Doctrine of the Faith, further clarified that it is "morally licit" for Catholics to receive vaccines derived from fetal cell lines or in which such lines were used in testing or development, because "passive material cooperation in the procured abortion from which these cell lines originate is, on the part of those making use of the resulting vaccines, remote" and "does not and should not in any way imply that there is a moral endorsement of the use of cell lines proceeding from aborted fetuses".[70]

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Further reading

External links

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