Chloramine-T
Names | |
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Preferred IUPAC name
Sodium chloro(4-methylbenzene-1-sulfonyl)azanide | |
Other names
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Identifiers | |
3D model (
JSmol ) |
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ChEBI | |
ChEMBL | |
ChemSpider | |
ECHA InfoCard
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100.004.414 |
EC Number |
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KEGG | |
PubChem CID
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UNII |
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CompTox Dashboard (EPA)
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Properties | |
C7H7ClNO2S·Na C7H7ClNO2S·Na·(3H2O) (hydrate) | |
Molar mass | 227.64 g/mol 281.69 g/mol (trihydrate) |
Appearance | White powder |
Density | 1.4 g/cm3 |
Melting point | Releases chlorine at 130 °C (266 °F; 403 K) Solid melts at 167–169 °C |
>100 mg/mL (hydrate)[1] | |
Pharmacology | |
QP53AB04 (WHO )
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Hazards | |
Occupational safety and health (OHS/OSH): | |
Main hazards
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Corrosive |
GHS labelling: | |
Danger | |
H302, H314, H334 | |
P260, P261, P264, P270, P280, P285, P301+P312, P301+P330+P331, P303+P361+P353, P304+P340, P304+P341, P305+P351+P338, P310, P321, P330, P342+P311, P363, P405, P501 | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Chloramine-T is the organic compound with the formula CH3C6H4SO2NClNa. Both the anhydrous salt and its trihydrate are known. Both are white powders. Chloramine-T is used as a reagent in organic synthesis.[2][3] It is commonly used as cyclizing agent in the synthesis of aziridine, oxadiazole, isoxazole and pyrazoles.[3] It's inexpensive, has low toxicity and acts as a mild oxidizing agent. In addition, it also acts as a source of nitrogen anions and electrophilic cations. It may undergo degradation on long term exposure to atmosphere such that care must be taken during its storage.
Reactions
Chloramine-T contains active (
It is prepared by oxidation of toluenesulfonamide with sodium hypochlorite, with the latter being produced in situ from sodium hydroxide and chlorine (Cl2):[2]
Uses
Reagent in amidohydroxylation
The
Oxidant
Chloramine-T is a strong oxidant.[
It converts
Certifications
- EN 1276 Bactericidal
- EN 13713 Bactericidal
- EN 14675 Virucidal
- EN 14476 Virucidal Norovirus
- EN 1650 Fungicidal
- EN 13704 Sporicidal Clostridium difficile
References
- ^ "Chloramine-T hydrate". Sigma-Aldrich.
- ^ .
- ^ ISSN 1319-6103.
- doi:10.1039/b111276g.
- ISBN 978-3527306732.
- ^ Rösch, F. Radiochemistry and Radiopharmaceutical Chemistry in Life Sciences. Vol. 4. Dordrecht, Boston, London: Kluwer Academic Publishers.
This article needs additional citations for verification. (November 2011) |
External links
- M. Shetty, T. B. Gowda (2004). "A Study of Substituent Effect on the Oxidative Strengths of N-Chloroarenesulphonamides: Kinetics of Oxidation of Leucine and Isoleucine in Aqueous Acid Medium". Zeitschrift für Naturforschung. 59: 63–72. S2CID 46154131.
- Chemicalland21.com: Chloramine T (Tosylchloramide sodium)
- InChem.org: Chloramine T
- "Disifin USA". Archived from the original on 2009-12-25. Retrieved 2010-02-09.