Chlorophenylsilatrane

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1-(4-Chlorophenyl)silatrane
Names
IUPAC name
1-(4-Chlorophenyl)-2,8,9-trioxa-5-aza-1-silabicyclo[3.3.3]undecane
Other names
RS-150
Caswell No. 213B
1-(p-Chlorophenyl)silatrane
5-(p-Chlorophenyl)silatrane
5-(4-Chlorophenyl)silatrane
Identifiers
3D model (
JSmol
)
ChemSpider
ECHA InfoCard
 100.252.129 Edit this at Wikidata
UNII
  • InChI=1S/C12H16ClNO3Si/c13-11-1-3-12(4-2-11)18-15-8-5-14(6-9-16-18)7-10-17-18/h1-4H,5-10H2
    Key: IKFVTMCLFHXPQF-UHFFFAOYSA-N
  • c1cc(ccc1[Si]23OCCN(CCO2)CCO3)Cl
Properties
C12H16ClNO3Si
Molar mass 285.8 g/mol
Appearance odorless, white powder[1]
Melting point 230-235 °C[1]
<0.2 g/L[1]
Solubility in Chloroform, Benzene soluble[1]
Hazards
Occupational safety and health (OHS/OSH):
Main hazards
 Extremely toxic
Lethal dose or concentration (LD, LC):
1-4 mg/kg (rats, oral)[1]
3000 mg/kg (rats, dermal)[1]
0.9-2.0 mg/kg (mice, oral)[1]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

1-(4-Chlorophenyl)silatrane is an extremely toxic

organosilicon compound which was developed by M&T Chemicals as a single-dose rodenticide.[1] It was never registered as rodenticide,[2] except for experimental use.[1] 1-(4-Chlorophenyl)silatrane was one of the chemicals studied in the Project Coast.[3][4]

Toxicity

1-(4-Chlorophenyl)silatrane is a GABA receptor antagonist[5] and it destroys nervous functions in the central nervous system of vertebrates, primarily in the brain and possibly in the brain stem.[6][7][8] It's a rapid acting convulsant, causing convulsions within 1 minute in mice and rats. Death occurred within 5 minutes.[9] It is therefore likely to induce poison shyness.[2] In field trials, it was less effective than zinc phosphide against wild rats.[10]

See also

References

  1. ^ a b c d e f g h i Crabtree, D. Glen; Beiter, Charles B.; Schwarcz, Morton (1970). "5-p-Chlorophenyl silatrane, a new single-dose rodenticide". Chemical Report by M&T Chemicals Inc.
  2. ^
    ISSN 0250-8052
    .
  3. ^ "South Africa Chemical Chronology" (PDF). NTI.org. Nuclear Threat Initiative. 2005-04-23. Retrieved 2020-07-31.
  4. S2CID 143175071
    .
  5. PMID 2415350
    .
  6. PMID 1084063
    .
  7. ^ Mattson, H.; Brandt, K.; Heilbronn, E. (21–26 August 1977). Proceedings of the International Society of Neurochemistry. Sixth International Meeting of the International Society for Neurochemistry. Copenhagen, Denmark. p. 56.
  8. PMID 388722
    .
  9. PMID 4529452
    .
  10. PMID 4529041
    .
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