Chlorothiazide

Source: Wikipedia, the free encyclopedia.
Chlorothiazide
Clinical data
Trade namesDiuril, others
AHFS/Drugs.comMonograph
MedlinePlusa682341
Routes of
administration		By mouth, IV
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailabilitylow
MetabolismNil
Elimination half-life45 to 120 minutes
ExcretionRenal
Identifiers
  • 6-chloro-1,1-dioxo-2H-1,2,4-benzothiadiazine-7-sulfonamide
JSmol)
  • O=S(=O)(c1c(Cl)cc2c(c1)S(=O)(=O)/N=C\N2)N
  • InChI=1S/C7H6ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-3H,(H,10,11)(H2,9,12,13) checkY
  • Key:JBMKAUGHUNFTOL-UHFFFAOYSA-N checkY
  (verify)
Chlorothiazide
Names
Other names
6-Chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide-1,1-dioxide
Identifiers
3D model (
JSmol
)
ChEBI
ChEMBL
ChemSpider
DrugBank
ECHA InfoCard
 100.000.368 Edit this at Wikidata
KEGG
UNII
  • InChI=1S/C7H6ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-3H,(H,10,11)(H2,9,12,13) checkY
    Key: JBMKAUGHUNFTOL-UHFFFAOYSA-N checkY
  • O=S(=O)(c1c(Cl)cc2c(c1)S(=O)(=O)/N=C\N2)N
Properties
Melting point 342.5–343 °C (648.5–649.4 °F; 615.6–616.1 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Chlorothiazide, sold under the brand name Diuril among others, is an

antihypertensive.[1][2]

It is used both within the hospital setting or for personal use to manage excess fluid associated with

ICU setting, chlorothiazide is given to diurese a patient in addition to furosemide (Lasix). Working in a separate mechanism from furosemide and absorbed enterically as a reconstituted suspension administered through a nasogastric tube
(NG tube), the two drugs potentiate one another.

It was patented in 1956 and approved for medical use in 1958.[3] It is on the World Health Organization's List of Essential Medicines.[4]

Indications

Contraindications

Side effects

History

The research team of Merck Sharp and Dohme Research Laboratories of Beyer, Sprague, Baer, and Novello created a new series of medications, the thiazide diuretics, which includes chlorothiazide. They won an Albert Lasker Special Award in 1975 for this work.[6]

The structure has been determined by X-ray crystallography.[7]

See also

References

  1. doi:10.2174/157340208786241264
    .
  2. PMID 20528637
    .
  3. ISBN 9783527607495
    .
  4. hdl:10665/345533
    . WHO/MHP/HPS/EML/2021.02.
  5. ^ a b "Diuril (Chlorothiazide): Side Effects, Interactions, Warning, Dosage & Uses". RxList. Retrieved 2019-10-07.
  6. ^ "Historical Awards - The Lasker Foundation". The Lasker Foundation.
  7. doi:10.1021/cg1010049
    .
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