Chromosome instability syndrome

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Chromosomal breakage syndrome
)

Chromosome instability syndromes are a group of inherited conditions associated with chromosomal instability and breakage. They often lead to an increased tendency to develop certain types of malignancies.[1]

The following chromosome instability syndromes are known:

Neurodegenerative diseases

Chromosome instability syndromes include several inherited

.

Hypogonadism

Genes

ovarian failure.[2][3] The germline MCM8-MCM9 protein complex is most likely required for the resolution of double-strand breaks that occur during homologous recombination in the pachytene stage of meiosis I.[2]

References