Chronic neutrophilic leukemia
 | This article's lead section may be too short to adequately summarize the key points. (December 2015) |
| Chronic neutrophilic leukemia | |
|---|---|
| Other names | CNL[1] |
| Specialty | Hematology and oncology |
Chronic neutrophilic leukemia (CNL) is a rare
Signs and symptoms
The most common clinical finding is
Cause
The cause of CNL is currently unknown. An association between CNL and multiple myeloma has been suggested based on the observation of myeloma in 20% of CNL cases.[5] However, a clonal genetic abnormality has not been detected in these myeloma-associated cases of CNL, raising the possibility that the
Genetics
The majority (90%) of cases have not had detectable
Diagnosis
Laboratory findings
Peripheral blood neutrophilia (> 25 x 109/L) with
Sites of involvement
Peripheral
Bone marrow biopsy
On both the bone marrow aspirate and the core biopsy, a hypercellular marrow with an increased myeloid:
Spleen
Liver
Immunophenotype
No distinct immunophenotype abnormality for CNL has been described.[2] See OHSU 2013 findings of gene CSF3R, mutation p. T6181.
Epidemiology
This is a rare disease, with less than 100 cases reported. Of these cases, an equal male:female ratio was observed,[3] with cases typically seen in older adults.[4]
References
- ^ "Chronic neutrophilic leukemia | Genetic and Rare Diseases Information Center (GARD) – an NCATS Program". rarediseases.info.nih.gov. Archived from the original on 17 November 2019. Retrieved 17 November 2019.
- ^ ISBN 92-832-2411-6.
- ^ PMID 289288.
- ^ S2CID 19097693.
- PMID 8098719.
- PMID 9495373.