Ciclazindol

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Ciclazindol
Clinical data
Routes of
administration		Oral
ATC code
  • none
Pharmacokinetic data
MetabolismRenal[1]
Elimination half-life~32 hours[1]
ExcretionUrine, feces[1]
Identifiers
  • 10-(3-chlorophenyl)-3,4-dihydro-2H-pyrimido[1,2-a]indol-10-ol
JSmol)
  • Clc1cccc(c1)C3(O)c4c(N2\C3=N/CCC2)cccc4

Ciclazindol (WY-23409) is an

H1 receptor.[5][6][7] As suggested by its local anesthetic properties,[6] ciclazindol may also inhibit sodium channels. It is known to block potassium channels as well.[8][9]

The dosage in human volunteers is stated to be 25mg daily.[1] However, doses of up to 200mg have also been reported.[2] This is surprising since the dosage of mazindol is only 2-4mg per day.

Ciclazindol is reported to have an IC50 of 1.3nM for the dopamine transporter (cmp 23).[10]

See also

References

  1. ^
    PMID 843425
    .
  2. ^
    S2CID 30435450
    .
  3. ^
    S2CID 12961802
    .
  4. S2CID 28112402
    .
  5. ^
    S2CID 24199961
    .
  6. ^
    PMID 507990
    .
  7. PMID 6244029
    .
  8. PMID 1504725
    .
  9. PMID 8609901
    .
  10. PMID 8960553
    .