Ciguatoxin

Source: Wikipedia, the free encyclopedia.
Not to be confused with Cicutoxin.
Chemical structure of the ciguatoxin CTX1B

Ciguatoxins are a class of

ciguatera
.

There are several different chemicals in this class. "CTX" is often used as an abbreviation.

Toxic effect on humans

Ciguatoxins do not seem to harm the fish that carry them, but they are poisonous to humans. They cannot be smelled or tasted and cannot be destroyed by cooking.[1] Rapid testing for this toxin in food is not standard.

Some ciguatoxins lower the threshold for opening excitatory voltage-gated

ciguatera
.

Ciguatoxins are

lipophilic, able to cross the blood–brain barrier
, and can cause both central and peripheral neurologic symptoms.

The major symptoms will develop within 1–3 hours of toxin ingestion: vomiting, diarrhea, numbness of extremities, mouth and lips, reversal of hot and cold sensation, muscle and joint aches. The symptoms may last from days to weeks or even months depending on each individual situation. There is no known antidote, though several therapeutic targets have been identified.

ng/kg.[4]

Bioaccumulation

Ciguatoxin is produced by

lionfish, and amberjack. It also affects barracuda, snapper, hogfish, king mackerel, and sea bass.[5]

See also

References

  1. S2CID 222017205
    .
  2. PMID 22850668
    .
  3. PMID 26454262
    .
  4. ISBN 978-3-540-87895-7
    .
  5. ^ Yong, Shin Jie (2020-04-19). "Fishes Carrying This Incurable Poison Are on the Rise". Medium. Retrieved 2020-05-25.

External links

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