Claisen–Schmidt condensation

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In

α-hydrogen. It can be considered as a specific variation of the aldol condensation. This reaction is named after two of its pioneering investigators Rainer Ludwig Claisen and J. Gustav Schmidt, who independently published on this topic in 1880 and 1881.[1][2][3][page needed] An example is the synthesis of dibenzylideneacetone ((1E, 4E)-1,5-diphenylpenta-1,4-dien-3-one).[4]

Dibenzalacetone synthesis

benzaldehydes.[5]
Because the enolizable nucleophilic carbonyl compound and the electrophilic carbonyl compound are two different chemicals, the Claisen–Schmidt reaction is an example of a crossed aldol process.

References

  1. doi:10.1002/cber.188101402192
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  2. doi:10.1002/cber.188101401306
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  3. ISBN 0-471-85472-7
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  4. doi:10.1021/ed078p226
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  5. PMID 22231494.{{cite journal}}: CS1 maint: multiple names: authors list (link
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