Clobetasol propionate

Source: Wikipedia, the free encyclopedia.
Not to be confused with Clostebol propionate.

Clobetasol propionate
Clinical data
Pronunciation/kloʊˈbeɪtəsɒl/[1]
Trade namesDermovate, Temovate, Clovate, others
AHFS/Drugs.comMonograph
License data
Pregnancy
category
  • AU: B3
Topical
ATC code
Legal status
Legal status
  • US: WARNING[2]
  • In general: ℞ (Prescription only)
Identifiers
  • [17-(2'-Chloroacetyl)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate
JSmol)
  • ClCC(=O)[C@]3(OC(=O)CC)[C@]2(C[C@H](O)[C@]4(F)[C@@]/1(\C(=C/C(=O)\C=C\1)CC[C@H]4[C@@H]2C[C@@H]3C)C)C
  • InChI=1S/C25H32ClFO5/c1-5-21(31)32-25(20(30)13-26)14(2)10-18-17-7-6-15-11-16(28)8-9-22(15,3)24(17,27)19(29)12-23(18,25)4/h8-9,11,14,17-19,29H,5-7,10,12-13H2,1-4H3/t14-,17-,18-,19-,22-,23-,24-,25-/m0/s1 checkY
  • Key:CBGUOGMQLZIXBE-XGQKBEPLSA-N checkY
  (verify)

Clobetasol propionate is a

seborrheic dermatitis, and psoriasis.[3] It is applied to the skin as a cream, ointment, or shampoo.[3][4] Use should be short term and only if other weaker corticosteroids are not effective.[4] Use is not recommended in rosacea or perioral dermatitis.[3]

Common side effects include skin irritation, dry skin, redness, pimples, and

steroid receptors.[3]

Clobetasol propionate was patented in 1968 and came into medical use in 1978.

generic medication.[4] In 2021, it was the 162nd most commonly prescribed medication in the United States, with more than 3 million prescriptions.[7][8]

Medical uses

Clobetasol propionate is used for the treatment of various skin disorders including

GVHD of the skin.[10]

Clobetasol propionate is used cosmetically for skin whitening, although this use is controversial. The U.S. Food and Drug Administration has not approved it for that purpose, and sales without a prescription are illegal in the U.S. Nonetheless, skin-whitening creams containing this ingredient can sometimes be found in beauty supply stores in New York City and on the internet. It is also sold internationally, and does not require a prescription in some countries. Whitening creams with clobetasol propionate, such as Hyprogel, can make skin thin and easily bruised, with visible capillaries, and acne. It can also lead to hypertension, elevated blood sugar, suppression of the body's natural steroids, and stretch marks, which may be permanent.[11]

Clobetasol propionate is, along with mercury and hydroquinone, "amongst the most toxic and most used agents in lightening products." Many products sold illegally have higher concentrations of clobetasol propionate than is permitted for prescription drugs.[12]

Society and culture

Brand names

Clobetasol propionate is marketed and sold worldwide under numerous names, including Clobex, Clob-x (Colombia), Clovate, Clobet (Biolab Thailand) Clonovate (T.O. Chemicals, Thailand), Cormax (

GlaxoSmithKline
, Canada, Estonia, Pakistan, Switzerland, Ukraine, Portugal, Romania, Israel), Olux, ClobaDerm, Tenovate, Dermatovate (Brazil, Mexico), Butavate, Movate, Novate, Salac (Argentina), and Powercort, Lotasbat and Kloderma (Indonesia), Lemonvate and Clobesol (Italy), Dovate (South Africa), Delor (Ethiopia), Psovate (Turkey) or Skineal (Nigeria).

References

  1. ^ "Clobetasol Propionate Topical Ointment 0.05% Information". Drug Encyclopedia. Kaiser Permanente. Archived from the original on 28 August 2021. Retrieved 9 October 2009.
  2. FDA
    . Retrieved 22 October 2023.
  3. ^ a b c d e f "Clobetasol Propionate Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 28 August 2021. Retrieved 13 April 2019.
  4. ^
    ISBN 978-0-85711-338-2
    .
  5. ^ "Clobetasol topical Use During Pregnancy". Drugs.com. Archived from the original on 28 August 2021. Retrieved 13 April 2019.
  6. ISBN 9783527607495. Archived
    from the original on 28 November 2023. Retrieved 3 September 2020.
  7. ^ "The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
  8. ^ "Clobetasol - Drug Usage Statistics". ClinCalc. Archived from the original on 18 January 2024. Retrieved 14 January 2024.
  9. S2CID 205588376
    .
  10. ^ E. Fougera and Co. "Clobetasol Propionate Cream Usp, 0.05% Clobetasol Propionate Ointment USP, 0.05%". Daily Med. U.S. National Library of Medicine. Archived from the original on 23 May 2009. Retrieved 3 July 2009.
  11. ^ Saint Louis C (15 January 2010). "Creams Offering Lighter Skin May Bring Risks". New York Times. Archived from the original on 19 February 2017. Retrieved 24 February 2017.
  12. PMID 27372064
    .
  13. ^ "Dermovate 0.05% W/V Ointment - Clobetasol Topical(0.05% W/V)". Glaxo SmithKline Pharmaceuticals Ltd. GNHIndia.com. Archived from the original on 16 July 2021. Retrieved 16 July 2021.
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