Clobetasone
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| Clinical data | |
|---|---|
| Trade names | Eumovate |
| Other names | (8S,9R,10S,13S,14S,16S,17R)-17-(2-Chloroacetyl)-9-fluoro-17-hydroxy-10,13,16-trimethyl-7,8,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthrene-3,11-dione |
| AHFS/Drugs.com | Micromedex Detailed Consumer Information |
| Routes of administration | topical |
| ATC code | |
| Identifiers | |
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JSmol) | |
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| (verify) | |
Clobetasone (
It is available as clobetasone butyrate under the brand names Eumosone or Eumovate
Trimovate also contains
Uses
In
In ophthalmology, clobetasone butyrate 0.1% eye drops have been shown to be safe and effective in the treatment of dry eyes in Sjögren syndrome. Sjögren syndrome is an autoimmune disorder that affects the moisture producing glands of the body causing many symptoms including dry eyes.[6] When compared to other corticosteroid eye drops; clobetasone butyrate showed only minimal rises in intraocular pressure. Increased pressure within the eye can lead to glaucoma.[7][8][9]
Adverse effects
Side effects associated with clobetasone cream and ointment include: burning, irritation, itching, thinning of the skin, and changes in skin color.[5][10]
Contraindications
The following should not be treated with clobetasone with nystatin and oxytetracycline:
- Patients with known history of hypersensitivity to clobetasone butyrate, nystatin, oxytetracycline or any components of the formulation
- Primary cutaneous viral infections (Common viral skin infections include herpes simplex virus infection, herpes zoster, cutaneous and genital warts, and molluscum contagiosum.)[11]
- Primary infected skin lesions caused by infection with fungi, bacteria or yeasts (Fungal infections of the skin commonly seen in family practice include the various forms of tinea: tinea corporis, tinea gladiatorum, tinea cruris, tinea pedis, tinea capitis, and tinea unguium (e.g., onychomycosis).)[11]
- Cutaneous infections caused by methicillin resistant Staphylococcus aureus (MRSA), Pseudomonas species, Proteus species Serratia species or Group B streptococcal infection (Streptococcus B., Group B streptococcal infection, also known as Group B streptococcal disease or just Group B strep, is the infection caused by the bacterium Streptococcus agalactiae(S. agalactiae) also known as group B streptococcus or GBS)
- Rosacea
- Acne vulgaris
- Prurituswithout inflammation
Serious Contraindications
- Pseudomembranous colitis - C. Diff. Colitis, also called: clostridium difficile colitis, or Pseudomembranous colitis has been reported with the use of antibiotics and may range in severity from mild to life-threatening.
- Reversible hypothalamic-pituitary-adrenal (HPA) axis suppression - Manifestations of hypercortisolism (adrenals; was previously called Adrenal Fatigue.)[12]
See also
References
- ^ "United Nations Statistics Division - Classifications Registry - Alphabetical index for HS 2002 Entries starting with 'C' (page 310 of 422)". Archived from the original on 2011-06-08. Retrieved 2007-12-11.
- PMID 1164639.
- ^ "Eumovate cream/ointment". NetDoctor.co.uk. 2017-07-05.
- ^ "Trimovate". Electronic Medicines Compendium (EMC). Datapharm Ltd.
- ^ a b "Euvomate Medication Guide". GlaxoSmithKline. Archived from the original on 30 January 2014.
- S2CID 20730843.
- PMID 6986899.
- PMID 7032579.
- PMID 7028089.
- ^ "Clobetason Butyrate". WebMD. Archived from the original on March 2, 2012.
- ^ PMID 31995350– via PubMed.
- ^ "Overcoming HPA Axis Suppression (Formerly Known as Adrenal Fatigue)". BodyLogicMD. October 23, 2017.