Codeine/paracetamol

Source: Wikipedia, the free encyclopedia.

Codeine/paracetamol
Combination of
CodeineOpioid analgesic
paracetamolAnilide analgesic
Clinical data
Trade namesTylenol with codeine, others
MedlinePlusa601005
License data
Routes of
administration		By mouth
ATC code
Legal status
Legal status
"Acetaminophen and Codeine Phosphate tablet". DailyMed. 31 July 2020. Archived from the original on 18 March 2022. Retrieved 17 July 2022.</ref>[1]
Identifiers
CAS Number
PubChem CID
ChemSpider
KEGG
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Codeine/paracetamol, also called codeine/acetaminophen and co-codamol, is a

non-steroidal anti-inflammatory drugs (NSAIDs; such as ibuprofen, aspirin, and naproxen) alone do not sufficiently relieve symptoms.[3][4]

In 2021, it was the 176th most commonly prescribed medication in the United States, with more than 2 million prescriptions.[5][6]

Side effects

The most common side effects include constipation, nausea, and drowsiness.[7] Others include

vivid dreams, dry mouth, and addiction.[8]

Genetic differences between people cause differing rates of metabolism of codeine to

respiratory depression in a breastfed baby.[9]

Society and culture

Availability

Of the European Union (EU) member states, 11 allow over-the-counter sale of solid dosage forms of codeine, including codeine/paracetamol; they are Bulgaria, Cyprus, Denmark, France, Ireland, Latvia, Lithuania, Malta, Poland, Romania, and Slovenia.[10]

References

  1. ^ "Acetaminophen and Codeine Phosphate solution". DailyMed. 25 May 2022. Archived from the original on 11 May 2021. Retrieved 17 July 2022.
  2. ^ "Acetaminophen with Codeine Product information". Health Canada. 25 April 2012. Retrieved 13 September 2022.
  3. ^ a b "Boots Paracetamol & Codeine 500mg/8mg Tablets - Patient Information Leaflet (PIL)". (emc). 30 November 2021. Archived from the original on 18 July 2022. Retrieved 17 July 2022.
  4. ^ a b "Co-Codamol 15/500 Tablets - Summary of Product Characteristics (SmPC)". (emc). 25 March 2021. Archived from the original on 5 August 2021. Retrieved 17 July 2022.
  5. ^ "The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
  6. ^ "Acetaminophen; Codeine - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
  7. ^ "Co-codamol for adults: painkiller containing paracetamol and codeine". National Health Service. 19 December 2018. Archived from the original on 14 January 2022. Retrieved 16 April 2021.
  8. PMID 26768736
    .
  9. ^ "Codeine Use While Breastfeeding May Be Dangerous". CTV News. 20 August 2008. Archived from the original on 1 September 2008. Retrieved 13 August 2020.
  10. PMID 26215740. Archived
    from the original on 25 March 2022. Retrieved 8 July 2020.
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