Collagenase
Chr. 11 q21-q22 | |||||||
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UniProt | P22894 | ||||||
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Other data | |||||||
EC number | Chromosome = 11 3.4.24.3 Chromosome = 11 | ||||||
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Peptidase M9 | |||||||||
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Identifiers | |||||||||
Symbol | Peptidase M9 | ||||||||
Pfam | PF01752 | ||||||||
Pfam clan | CL0126 | ||||||||
InterPro | IPR013510 | ||||||||
MEROPS | M9 | ||||||||
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Collagenases are
Collagen, a key component of the animal extracellular matrix, is made through cleavage of pro-collagen by collagenase once it has been secreted from the cell. This stops large structures from forming inside the cell itself.
In addition to being produced by some bacteria, collagenase can be made by the body as part of its normal immune response. This production is induced by
Therapeutic uses
Collagenases have been approved for medical uses for:
- treatment of Xiaflex).
- wound healing[2] (Santyl)
- cellulite (Qwo)
The MEROPS M9 family
This group of metallopeptidases constitutes the MEROPS peptidase family M9, subfamilies M9A and M9B (microbial collagenase, clan MA(E)). The protein fold of the peptidase domain for members of this family resembles that of thermolysin, the type example for clan MA and the predicted active site residues for members of this family and thermolysin occur in the motif HEXXH.[3]
Analysis of the
Other uses
Collagenases may be used for tenderizing meat in a manner similar to widely used tenderizers papain, bromelain and ficain.[5]
See also
References
- ISBN 978-0-321-39603-7.
- PMID 16921413.
- ^ )
- ^ PMID 8282691.
- PMID 23442615.
External links
- Collagenases at the U.S. National Library of Medicine Medical Subject Headings (MeSH)