Colton antigen system
The Colton antigen system (Co) is present on the membranes of
red blood cells and in the tubules of the kidney[1] and helps determine a person's blood type. The Co antigen is found on a protein called aquaporin-1 which is responsible for water homeostasis and urine concentration.[2]
The Co antigen is important in
transfusion reaction such as hemolytic anemia or alloimmunization. Antibodies against the Colton antigen may also cause hemolytic disease of the newborn, in which a pregnant woman's body creates antibodies against the blood of her fetus, leading to destruction of the fetal blood cells.[3]
References
- Online Mendelian Inheritance in Man (OMIM): 110450 OMIM entry for the Colton antigen
External links
- Colton at NIH
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