Complement 2 deficiency
Complement 2 deficiency | |
---|---|
Other names | C2 deficiency, Complement component 2 deficiency, C2D. |
Structure of the C2 protein | |
Specialty | Hematology |
Complement 2 deficiency is a type of complement deficiency caused by any one of several different alterations in the structure of complement component 2.
It has been associated with an increase in infections.[1][2]
It can present similarly to
systemic lupus erythematosus (SLE).[3]
Signs and symptoms
C2D is linked to
Systemic Lupus Erythematosus (SLE) or SLE-like disease.[4]
Complement deficiency has historically been associated with early, severe bacterial infections among children.[5] Infection susceptibility is frequently observed.[6]
C2D is linked to abnormalities in serum
Haemophilus influenza type b and Neisseria meningitis are two other infections commonly seen in C2D patients.[8]
Complications
In roughly 10% of patients, a C2 deficiency is linked to an illness that resembles
Anti-Ro antibodies will be present in approximately 50% of the population.[11]
cutaneous lupus erythematosus can occur. Renal and neuropsychiatric disease, on the other hand, is thought to be uncommon in these SLE patients.[4]
C2 deficiency has also been linked to
See also
- Systemic Lupus Erythematosus
- Complement deficiency
References
- S2CID 1198276.
- ISBN 978-0-7817-3371-7. Retrieved 30 May 2010.
- ISBN 978-81-312-2163-1. Retrieved 13 November 2010.
- ^ S2CID 243396344. Retrieved November 18, 2023.
- PMID 19758139.
- ^ PMID 1889047.
- PMID 15643297. Retrieved November 18, 2023.
- PMID 20930072.
- PMID 12110148.
- PMID 11079100. Retrieved November 18, 2023.
- ^ "UpToDate". UpToDate. Retrieved November 19, 2023.
- PMID 4583776.
- PMID 1090155. Retrieved November 18, 2023.
- PMID 3467658. Retrieved November 18, 2023.
- PMID 2582254. Retrieved November 18, 2023.
Further reading
- Sjöholm, A.G.; Jönsson, G.; Braconier, J.H.; Sturfelt, G.; Truedsson, L. (2006). "Complement deficiency and disease: An update". Molecular Immunology. 43 (1–2). Elsevier BV: 78–85. PMID 16026838.