Complement 2 deficiency

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Complement 2 deficiency
Other namesC2 deficiency, Complement component 2 deficiency, C2D.
Structure of the C2 protein
SpecialtyHematology Edit this on Wikidata

Complement 2 deficiency is a type of complement deficiency caused by any one of several different alterations in the structure of complement component 2.

It has been associated with an increase in infections.[1][2]

It can present similarly to

systemic lupus erythematosus (SLE).[3]

Signs and symptoms

C2D is linked to

Systemic Lupus Erythematosus (SLE) or SLE-like disease.[4]

Complement deficiency has historically been associated with early, severe bacterial infections among children.[5] Infection susceptibility is frequently observed.[6]

C2D is linked to abnormalities in serum

Haemophilus influenza type b and Neisseria meningitis are two other infections commonly seen in C2D patients.[8]

Complications

In roughly 10% of patients, a C2 deficiency is linked to an illness that resembles

Anti-Ro antibodies will be present in approximately 50% of the population.[11]

cutaneous lupus erythematosus can occur. Renal and neuropsychiatric disease, on the other hand, is thought to be uncommon in these SLE patients.[4]

C2 deficiency has also been linked to

See also

References

Further reading

External links