Complement factor B
| CFB | |||
|---|---|---|---|
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl |
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|---|---|---|---|---|---|---|---|---|---|
| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 6: 31.95 – 31.95 Mb | Chr 17: 35.08 – 35.08 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Complement factor B is a protein that in humans is encoded by the CFB gene.[5]
Function
This gene encodes complement factor B, a component of the
chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2.[5]
| C4 (C) | FB (A) | C3 | CH50 | Conditions |
|---|---|---|---|---|
| · | ↓ | ↓ | ↓ | PSG, C3 NeF AA
|
| ↓ | · | ↓ | · | HAE, C4D |
| · | · | · | ↓ | TCPD |
| ↓ | ·/↓ | ↓ | ↓ | SLE
|
| ↑ | ↑ | ↑ | ↑ | inflammation |
References
- ^ a b c ENSG00000239754, ENSG00000243649, ENSG00000241253, ENSG00000242335, ENSG00000241534, ENSG00000204359 GRCh38: Ensembl release 89: ENSG00000243570, ENSG00000239754, ENSG00000243649, ENSG00000241253, ENSG00000242335, ENSG00000241534, ENSG00000204359 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000090231 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: CFB complement factor B".
Further reading
- Ambrus JL, Peters MG, Fauci AS, Brown EJ (March 1990). "The Ba fragment of complement factor B inhibits human B lymphocyte proliferation". Journal of Immunology. 144 (5): 1549–53. PMID 2307833.
- Bradley DT, Zipfel PF, Hughes AE (June 2011). "Complement in age-related macular degeneration: a focus on function". Eye. 25 (6): 683–93. PMID 21394116.
- Campbell RD (January 1987). "The molecular genetics and polymorphism of C2 and factor B". British Medical Bulletin. 43 (1): 37–49. PMID 3315100.
- Campbell RD, Bentley DR, Morley BJ (September 1984). "The factor B and C2 genes". Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 306 (1129): 367–78. PMID 6149579.
- Yu CY (1999). "Molecular genetics of the human MHC complement gene cluster". Experimental and Clinical Immunogenetics. 15 (4): 213–30. S2CID 25061446.
- Rawal N, Pangburn MK (March 2001). "Structure/function of C5 convertases of complement". International Immunopharmacology. 1 (3): 415–22. PMID 11367526.
- Arnason A, Larsen B, Marshall WH, Edwards JH, Macintosh P, Olaisen B, Teisberg P (August 1977). "Very close linkage between HLA-B and Bf inferred from allelic association". Nature. 268 (5620): 527–8. S2CID 4262433.
- Barnum SR, Ishii Y, Agrawal A, Volanakis JE (October 1992). "Production and interferon-gamma-mediated regulation of complement component C2 and factors B and D by the astroglioma cell line U105-MG". The Biochemical Journal. 287. 287 ( Pt 2) (2): 595–601. PMID 1445220.
- Yancey KB, Overholser O, Domloge-Hultsch N, Li LJ, Caughman SW, Bisalbutra P (March 1992). "Human keratinocytes and A-431 cells synthesize and secrete factor B, the major zymogen protease of the alternative complement pathway". The Journal of Investigative Dermatology. 98 (3): 379–83. PMID 1545147.
- Niemann MA, Bhown AS, Miller EJ (March 1991). "The principal site of glycation of human complement factor B". The Biochemical Journal. 274. 274 ( Pt 2) (2): 473–80. PMID 2006911.
- Davrinche C, Abbal M, Clerc A (1991). "Molecular characterization of human complement factor B subtypes". Immunogenetics. 32 (5): 309–12. S2CID 13698345.
- Farries TC, Lachmann PJ, Harrison RA (August 1988). "Analysis of the interaction between properdin and factor B, components of the alternative-pathway C3 convertase of complement". The Biochemical Journal. 253 (3): 667–75. PMID 3140783.
- Wu LC, Morley BJ, Campbell RD (January 1987). "Cell-specific expression of the human complement protein factor B gene: evidence for the role of two distinct 5'-flanking elements". Cell. 48 (2): 331–42. S2CID 32752642.
- Campbell RD, Porter RR (July 1983). "Molecular cloning and characterization of the gene coding for human complement protein factor B". Proceedings of the National Academy of Sciences of the United States of America. 80 (14): 4464–8. PMID 6308626.
- Morley BJ, Campbell RD (January 1984). "Internal homologies of the Ba fragment from human complement component Factor B, a class III MHC antigen". The EMBO Journal. 3 (1): 153–7. PMID 6323161.
- Christie DL, Gagnon J (January 1983). "Amino acid sequence of the Bb fragment from complement Factor B. Sequence of the major cyanogen bromide-cleavage peptide (CB-II) and completion of the sequence of the Bb fragment". The Biochemical Journal. 209 (1): 61–70. PMID 6342610.
- Mole JE, Anderson JK, Davison EA, Woods DE (March 1984). "Complete primary structure for the zymogen of human complement factor B". The Journal of Biological Chemistry. 259 (6): 3407–12. PMID 6546754.
- Woods DE, Markham AF, Ricker AT, Goldberger G, Colten HR (September 1982). "Isolation of cDNA clones for the human complement protein factor B, a class III major histocompatibility complex gene product". Proceedings of the National Academy of Sciences of the United States of America. 79 (18): 5661–5. PMID 6957884.
- Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
- Mejía JE, Jahn I, de la Salle H, Hauptmann G (January 1994). "Human factor B. Complete cDNA sequence of the BF*S allele". Human Immunology. 39 (1): 49–53. PMID 8181962.
External links
- GeneReviews/NCBI/NIH/UW entry on Atypical Hemolytic-Uremic Syndrome
- OMIM entries on Atypical Hemolytic-Uremic Syndrome
- The MEROPS online database for peptidases and their inhibitors: S01.196
- Complement+Factor+B at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Overview of all the structural information available in the PDB for UniProt: P00751 (Complement factor B) at the PDBe-KB.
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