Complications of traumatic brain injury
Symptoms that may occur after a concussion – a minor form of traumatic brain injury – are referred to as post-concussion syndrome.
Effects on unconsciousness
Generally, there are six abnormal
- Stupor is a state of partial or near complete unconsciousness in which the patient is lethargic, immobile, and has a reduced response to stimuli.[3]
- Coma is a state in which the patient is totally unconscious and cannot be aroused even with strong stimuli.[4]
- Persistent vegetative state is a condition in which awake patients are unconscious and unaware of their surroundings and the cerebral cortex is not functioning.[5] A vegetative state can result from diffuse injury to the cerebral hemispheres of the brain without damage to the lower brain and brainstem. The vegetative state is considered permanent if it persists for 12 months after TBI or 3 months after causes other than trauma.[6]
- A minimally conscious state is a condition in which patients have a reduced level of arousal and may appear, on the surface, to be in a persistent vegetative state but are capable of demonstrating the ability to actively process information.
- Locked-in syndrome is a condition in which a patient is aware and awake, but cannot move or communicate due to complete paralysis of the body.[7] Voluntary control of eye movements or blinking may be spared, permitting the detection of conscious awareness and enabling the establishment of functional communication.[7]
- Brain death is the irreversible loss of measurable brain function, with loss of any integrated activity among distinct areas of the brain.[8] Breathing and heart function must be maintained with assistive devices.[8]
Disorders of consciousness affect a significant number of people with severe TBI; of those with severe TBI discharged from a hospital, 10%-15% are in a vegetative state, and of this number only half regain consciousness within one to three years.[6]
Cognitive deficits
Most patients with severe TBI who recover consciousness experience
Alzheimer's disease (AD) is a progressive, neurodegenerative disease characterized by dementia, memory loss, and deteriorating cognitive abilities. Research suggests an association between head injury in early adulthood and the development of AD later in life; the more severe the head injury, the greater the risk of developing AD.[1] Some evidence indicates that a head injury may interact with other factors to trigger the disease and may hasten the onset of the disease in individuals already at risk. For example, head-injured people who have a particular form of the protein apolipoprotein E (apoE4, a naturally occurring protein that helps transport cholesterol through the bloodstream) fall into this increased risk category.[1]
Patients with moderate to severe TBI have more problems with cognitive deficits than do those with mild TBI, but several mild TBIs may have an additive effect. About one in five career boxers is affected by chronic traumatic brain injury (CTBI), which causes cognitive, behavioral, and physical impairments.
Communication problems
Language and communication problems are common disabilities in TBI patients. Some may experience aphasia, difficulty with understanding and producing spoken and written language; or they may have difficulty with the more subtle aspects of communication, such as body language and emotional, non-verbal signals. Some may have problems with intonation or inflection, called prosodic dysfunction. Problems with spoken language may occur if the part of the brain that controls speech muscles is damaged. In this disorder, called dysarthria, the patient can think of the appropriate language, but cannot easily speak the words because they are unable to use the muscles needed to form the words and produce the sounds. Speech is often slow, slurred, and garbled.[1]
Sensory deficits
TBI patients may have sensory problems, especially problems with
Emotional and behavioral problems
TBI may cause emotional or behavioral problems and changes in personality.
Behavioral symptoms that can follow TBI include disinhibition, inability to control anger, impulsiveness, lack of initiative, inappropriate sexual activity, and changes in personality.[9] Different behavioral problems are characteristic of the location of injury; for instance, frontal lobe injuries often result in disinhibition and inappropriate or childish behavior, and temporal lobe injuries often cause irritability and aggression.[19]
Physical complications
Pain, especially headache, is a common complication following a TBI.
The risk of post-traumatic seizures increases with severity of trauma (image at right) and is particularly elevated with certain types of brain trauma such as cerebral contusions or hematomas.[22] As many as 50% of people with penetrating head injuries will develop seizures.[20] People with early seizures, those occurring within a week of injury, have an increased risk of post-traumatic epilepsy (recurrent seizures occurring more than a week after the initial trauma)[23] though seizures can appear a decade or more after the initial injury and the common seizure type may also change over time. Generally, medical professionals use anticonvulsant medications to treat seizures in TBI patients within the first week of injury only[24] and after that only if the seizures persist.
Coagulopathy after a TBI can appear, due to specific biochemical processes, which can in turn lead to further serious complications, such as progressive hemorrhagic injury.[25]
Neurostorms may occur after a severe TBI. The lower the Glasgow Coma Score (GCS), the higher the chance of Neurostorming. Neurostorms occur when the patient's Autonomic Nervous System (ANS), Central Nervous System (CNS), Sympathetic Nervous System (SNS), and Parasympathetic nervous system (PSNS) become severely compromised.[26] This in turn can create the following potential life-threatening symptoms: increased intra-cranial pressure (ICP), tachycardia, tremors, seizures, fevers, increased blood pressure, increased Cerebral Spinal Fluid (CSF), and diaphoresis.[26] A variety of medication may be used to help decrease or control neurostorm episodes.[27]
Parkinson's disease and other motor problems as a result of TBI are rare but can occur. Parkinson's disease, a chronic and progressive disorder, may develop years after TBI as a result of damage to the basal ganglia. Other movement disorders that may develop after TBI include tremor, ataxia (uncoordinated muscle movements), and myoclonus (shock-like contractions of muscles).[1]
Injuries to the base of the skull can damage nerves that emerge directly from the brain (cranial nerves). Cranial nerve damage may result in:
- Paralysis of facial muscles
- Damage to the nerves responsible for eye movements, which can cause double vision
- Damage to the nerves that provide sense of smell
- Loss of vision
- Loss of facial sensation
- Swallowing problems[28]
Any damage to the head or brain usually results in some damage to the
Fluid and hormonal imbalances can also complicate treatment. Hormonal problems can result from dysfunction of the
Another common problem is spasticity. In this situation, certain muscles of the body are tight or hypertonic because they cannot fully relax.[29]
See also
References
- ^ a b c d e f g h i j k l m Office of Communications and Public Liaison (February 2002). "Traumatic brain injury: Hope through research". NIH Publication No. 02-2478. National Institute of Neurological Disorders and Stroke, National Institutes of Health. Archived from the original on 2016-12-18. Retrieved 2008-08-17.
- PMID 9701095.
- ^ "Stupor" at Dorland's Medical Dictionary.
- ^ "Coma" at Dorland's Medical Dictionary
- ^ "Persistent vegetative state" at Dorland's Medical Dictionary.
- ^ ISBN 0-19-517355-4. Retrieved 2008-11-06.
- ^ a b "Locked-in syndrome" at Dorland's Medical Dictionary.
- ^ a b "Brain death" at Dorland's Medical Dictionary.
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- ^ a b "Neurostorm of the Century, Part 1 of 3: Medical Terminology". 30 January 2017.
- ^ "NeuroStorm of the Century, Part 3 of 3: A New Way of Life". 30 January 2017.
- ^ "Traumatic brain injury Complications - Mayo Clinic". Mayo Clinic. Retrieved 2017-01-31.
- ^ "Brain Injury: Complications and Medical Problems". 2016-12-12. Retrieved 2017-01-31.