Contursi Terme

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Contursi Terme
Comune
Comune di Contursi Terme
Coat of arms
Location of Contursi Terme
UTC+2 (CEST)
Postal code	84024
Dialing code	0828
Patron saint	Saint Donatus
Saint day	7 August
Website	Official website

Contursi Terme (Contursano: Cundurs) is a village and comune in the province of Salerno in the Campania region of south-western Italy.

Early history

No secure identification of Contursi Terme, where ancient remains confirm a settlement at the confluence of the

The thermal baths, insecurely linked to notices by Roman writers, were described in a manuscript Balnea Contursi of 1231;[8] The fifteen thermal springs, with varying mineral content, have retained their curative reputation, for bathing, both in warm pools and in a cold plunge, and for drinking.

Parkinson's disease

Families from the village have played an important role in the understanding of Parkinson's disease. In 1986, Larry Golbe, a doctor based at the University of Medicine and Dentistry of New Jersey, came across a family with six Parkinson's patients, and found that they had originated in Contursi.^[9] A few months later he found a second family with several Parkinson's patients, who also had ancestors from the village.^[9] This prompted Golbe to collaborate with Giuseppe DiIorio at the University of Naples, to analyse the DNA from Contursani and people who had emigrated from the village across the world.^[9] They identified three families in Italy and three families in the US, all of whom were descendants from a single couple who lived in Contursi in the late 17th and early 18th centuries.^[9] Of 400 members of this extended family, known as the "Contursi kindred", 61 are known to have had Parkinson's.^[9] This showed for the first time that Parkinson's could be inherited.^[10]

Geneticists Alice Lazzarini and William Johnson worked through the early 1990s trying to isolate the mutation that caused the disease.^[9] In 1996, a team led by Mihael Polymeropoulos at the National Institutes of Health located by linkage analysis the Parkinson's disease gene of the Contursi kindred on the long arm of human chromosome 4.^[11] In 1997, the same team identified a point mutation in the alpha-synuclein gene in the Contursi kindred as well as Greek pedigrees with Parkinson's disease.^[12][13] The NIH team and a team led by Maria Grazia Spillantini reported on alpha-synuclein deposits in Lewy bodies as well as alpha-synuclein inclusions in other neurodegenerative disorders.^[14][15]

References