Coronaridine

Source: Wikipedia, the free encyclopedia.
Coronaridine
Skeletal formula of coronaridine
Ball-and-stick model of the coronaridine molecule
Clinical data
ATC code
  • none
Identifiers
  • Methyl (1S,15R,17S,18S)-17-ethyl-3,13-diazapentacyclo[13.3.1.02,10.04,9.013,18]nonadeca-2(10),4,6,8-tetraene-1-carboxylate
JSmol)
  • CCC1CC2CC3(C1N(C2)CCC4=C3NC5=CC=CC=C45)C(=O)OC
  • InChI=1S/C21H26N2O2/c1-3-14-10-13-11-21(20(24)25-2)18-16(8-9-23(12-13)19(14)21)15-6-4-5-7-17(15)22-18/h4-7,13-14,19,22H,3,8-12H2,1-2H3/t13-,14+,19+,21-/m1/s1
  • Key:NVVDQMVGALBDGE-PZXGUROGSA-N

Coronaridine, also known as 18-carbomethoxyibogamine, is an alkaloid found in Tabernanthe iboga and related species, including Tabernaemontana divaricata for which (under the now obsolete synonym Ervatamia coronaria) it was named.[1]

Like

hypotensive activity.[3]

Chemistry

Congeners

Coronaridine congers are important in drug discovery and development due to multiple actions on different targets. They have ability to inhibit Cav2.2 channel,[4] modulate and inhibit subunits of nAChr selectively such as α9α10,[4] α3β4[5][6] and potentiate GABAA activity.[7]

Pharmacology

Coronaridine has been reported to bind to an assortment of molecular sites, including:

iboga alkaloids, coronaridine does not bind to either the σ1 or σ2 receptor.[10]

Sources

Plant sources
Family Plants
Apocynaceae
T. heyneana, T. litoralis, T. divaricata, T. penduliflora.[11]

See also

References

  1. PMID 12069962
    .
  2. ISBN 978-0262692656
    .
  3. PMID 4021514
    .
  4. ^
    S2CID 219705597
    .
  5. PMID 26022277
    .
  6. S2CID 3675707
    .
  7. S2CID 212734631
    .
  8. ^
    ISBN 978-0-12-398383-1
    .
  9. ^
    ISBN 978-0-203-01371-7
    .
  10. ^
    ISBN 978-0-08-086576-8
    .
  11. ^ "(−)-Coronaridine". ChEBI. European Bioinformatics Institute. CHEBI:3887.