Corwin Hansch

Source: Wikipedia, the free encyclopedia.
Corwin Hansch
Born
Corwin Herman Hansch

(1918-10-06)October 6, 1918
Organic Chemistry
InstitutionsPomona College
Manhattan Project
ThesisSyntheses of 3-substituted thianaphthenes (1944)
Doctoral advisorHarry Gustave Lindwall[1]

Corwin Herman Hansch (October 6, 1918 – May 8, 2011)[2] was a professor of chemistry at Pomona College in California. He became known as the 'father of computer-assisted molecule design.'[3]

Education and career

Hansch was born on October 6, 1918, in

PhD from New York University in 1944. He briefly worked as a postdoc at the University of Illinois Chicago
.

Hansch worked on the Manhattan Project at the

University of Munich with Rolf Huisgen.[6]

Hansch taught

Organic Chemistry
for many years at Pomona College, and was known for giving complex lectures without using notes. His course in Physical Bio-Organic Medicinal Chemistry was ground-breaking at an undergraduate level.

Hansch may be best known as the father of the concept of

quantitative structure-activity relationship (QSAR), the quantitative correlation of the physicochemical properties of molecules with their biological activities.[7]

He is also noted for the Hansch equation, which is used in

  • Multivariate Statistics - Multivariate statistics is a set of statistical tools to analyse data (e.g., chemical and biological) matrices using regression and/or pattern recognition techniques.
  • Hansch Analysis - Hansch analysis is the investigation of the quantitative relationship between the biological activity of a series of compounds and their physicochemical substituent or global parameters representing hydrophobic, electronic, steric and other effects using multiple regression correlation methodology.
  • Hansch-Fujita constant - The Hansch-Fujita constant describes the contribution of a substituent to the lipophilicity of a compound.

Research Interests:

Organic Chemistry
; Interaction of organic chemicals with living organisms, Quantitative Structure Activity Relationships (QSAR).

  • Fragment based regression analysis for
    quantitative structure-activity relationship
    (Hansch-analysis)

Death

He died of pneumonia on May 8, 2011, in Claremont, California, at 92.[2]

Notes

His research group at

Cynthia R. D. Selassie
, Suresh Babu Mekapati, and Alka Kurup.

The Journal of Computer-Aided Molecular Design carried four obituaries (as found in a Pubmed personal subject [ps] search).[8][9][10][6]

Among his students at Pomona was Jennifer Doudna, co-recipient of the 2020 Nobel Prize in Chemistry. Doudna has credited Hansch as an influence.[11]

Bibliography

A preliminary search in WorldCat and in PubMed, two among many relevant bibliographic and citation indexes, shows the following:

  • Books: WorldCat shows "53 works in 204 publications in 4 languages and 2,004 library holdings" for Hansch as "author, editor, other".[12] The top item in the list is "Exploring QSAR" by Corwin Hansch, Albert Leo and David Hoekman, an ACS professional reference book in 28 editions published between 1995 and 2014.
  • Journal articles: 281 Pubmed records[13]
  • Reviews: authored 33 reviews as indexed in Pubmed[14]
  • Title word search: 56 Pubmed records[15]

The Pomona College Archives holds reprints of Hansch's articles published between 1962 and 2009 in addition to other materials.[3]

See also

References

  1. doi:10.1002/qsar.19880070302
    .
  2. ^ a b Maugh, Thomas H. [II] (May 31, 2011). "Corwin Hansch dies at 92; scientist whose advances led to new drugs and chemicals". Los Angeles Times. Retrieved 5 August 2016.
  3. ^ a b Weber, Jamie (2013). "Guide to the Corwin Hansch Collection" (PDF). Pomona College Archives. Claremont, CA 91711. p. 3. Retrieved 5 August 2016.
  4. ^ "1975 Tolman Award Medalist, Dr. Corwin Hansch, Carnegie Professor of Chemistry, Pomona College". Southern California Section of the American Chemical Society. 22 August 2013.
  5. ^ Kendall, Mark. "In Memoriam: Corwin H. Hansch | Pomona College Magazine". Retrieved 2022-08-08.
  6. ^
    S2CID 207165325
    .
  7. ISSN 0001-4842
    .
  8. S2CID 35854016
    .
  9. PMID 21710390
    .
  10. S2CID 9840489
    .
  11. PMID 15574498
    .
  12. ^ "[WorldCat search - books authored, edited, contributed]". WorldCat. Retrieved August 5, 2016.
  13. ^ "281 articles, author search". Pubmed. Retrieved 5 August 2016.
  14. ^ "33 authored reviews". Pubmed. Retrieved 5 August 2016.
  15. ^ "title word Pubmed records". PubMed. Retrieved 5 August 2016.

External links

Retrieved from "https://en.wikipedia.org/w/index.php?title=Corwin_Hansch&oldid=1186043781"