Cowpea mosaic virus

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Cowpea mosaic virus
Structure of the Cowpea Mosaic Virus based on PDB 2BFU
Virus classification Edit this classification
(unranked): Virus
Realm: Riboviria
Kingdom: Orthornavirae
Phylum: Pisuviricota
Class: Pisoniviricetes
Order: Picornavirales
Family: Secoviridae
Genus: Comovirus
Species:
Cowpea mosaic virus
Synonyms

Cowpea mosaic virus, SB isolate

Cowpea mosaic virus (CPMV) is a non-enveloped

movement protein and coat protein. The virus particles are 28 nm in diameter and contain 60 copies each of a Large (L) and Small (S) coat protein. The structure is well characterised to atomic resolution, and the viral particles are thermostable. The identification of the virus is attributed to Lister and Thresh in 1955,[1] but it is now known as a variant of the Sunn-hemp mosaic virus.[2]

CPMV displays a number of features that can be exploited for

nanoscale biomaterial fabrication. Its genetic, biological and physical properties are well characterised, and it can be isolated readily from plants. There are many stable mutants already prepared that allow specific modification of the capsid surface. It is possible to attach a number of different chemicals to the virus surface[3][4] and to construct multilayer arrays of such nanoparticles on solid surfaces. This gives the natural or genetically engineered nanoparticles a range of properties which could be useful in nanotechnological applications such as biosensors, catalysis
and nanoelectronic devices.

One example use of CPMV particles is to amplify signals in

dimers that act as quenchers.[5] Another example is the use of CPMV as a nanoscale breadboard for molecular electronics.[6]

CPMV particles have also shown potential for in-situ vaccination in cancer immunotherapy[7]

References

  1. S2CID 4197728
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  2. .
  3. ^ Q. Wang, T. Lin, L. Tang, J.E. Johnson, and M.G. Finn.Angew. Chem. Int. Ed., 41(3), 459 (2002)
  4. ^ Q. Wang, T.R. Chan, R. Hilgraf, V.V. Fokin, K.B. Sharpless, and M.G. Finn. J. Am. Chem. Soc., 125, 3192 (2003).
  5. ^ Fluorescent signal amplification of carbocyanine dyes using engineered viral nanoparticles. Carissa M. Soto, Amy Szuchmacher Blum, Nikolai Lebedev, Gary J. Vora, Carolyn E. Meador, Angela P. Won, Anju Chatterji, John E. Johnson, and Banahalli R. Ratna, Journal of the American Chemical Society, 128, 5184 (2006).
  6. ^ An Engineered Virus as a Scaffold for Three-Dimensional Self-Assembly on the Nanoscale. Amy Szuchmacher Blum, Carissa M. Soto, Charmaine D. Wilson, Tina L. Brower, Steven K. Pollack, Terence L. Schull, Anju Chatterji, Tianwei Lin, John E. Johnson, Christian Amsinck, Paul Franzon, Ranganathan Shashidhar and Banahalli Ratna, Small, 7, 702 (2005).
  7. ^ "Plant Virus Used as Cancer Immunotherapy Agent". 2015-12-23.

External links