Crush syndrome
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Crush syndrome | |
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Collapsed building from 1985 Mexico earthquake. Earthquakes are a main cause of crush syndrome injuries. | |
Specialty | Emergency medicine |
Complications | Kidney failure |
Crush syndrome (also traumatic rhabdomyolysis or Bywaters' syndrome) is a medical condition characterized by major shock and kidney failure after a crushing injury to skeletal muscle. Crush injury is compression of the arms, legs, or other parts of the body that causes muscle swelling and/or neurological disturbances in the affected areas of the body, while crush syndrome is localized crush injury with systemic manifestations.[1] Cases occur commonly in catastrophes such as earthquakes, to individuals that have been trapped under fallen or moving masonry.
People with crushing damage present some of the greatest challenges in
Pathophysiology
Seigo Minami, a Japanese physician, first reported the crush syndrome in 1923.[2][3][4] He studied the pathology of three soldiers who died in World War I due to kidney failure. The renal changes were due to the buildup of excess myoglobin, resulting from the destruction of muscles from lack of oxygen. The progressive acute kidney failure is because of acute tubular necrosis.
The syndrome was later described by British physician Eric Bywaters in patients during the 1941 wartime bombing of London (the Blitz).[5][6] It is a reperfusion injury that appears after the release of the crushing pressure. The mechanism is believed to be the release into the bloodstream of muscle breakdown products—notably myoglobin, potassium and phosphorus—that are the products of rhabdomyolysis (the breakdown of skeletal muscle damaged by ischemic conditions).
The specific action on the kidneys is not understood completely, but may be due partly to nephrotoxic metabolites of myoglobin.
The most devastating systemic effects can occur when the crushing pressure is suddenly released, without proper preparation of the patient, causing reperfusion syndrome. In addition to tissue directly suffering the crush mechanism, tissue is then subjected to sudden reoxygenation in the limbs and extremities. Without proper preparation, the patient, with pain control, may be cheerful before recovery, but then may suddenly die shortly thereafter. This sudden failure is called the "smiling death".[7]
These systemic effects are caused by a traumatic rhabdomyolysis. As muscle cells die, they absorb sodium, water, and calcium; the rhabdomyolysis releases potassium, myoglobin, phosphate, thromboplastin, creatine, and creatine kinase.[citation needed]
Crush syndrome can directly come from compartment syndrome, if the injury is left untreated.[8] Symptoms include the 5 Ps: pain, pallor, paresthesias (pins and needles), paralysis, and pulselessness.[9]
Treatment
There is no distinct treatment option that can undo the effects and damage from rhabdomyolysis because it is a necrosis.[10] However, the rate of the pathology that can lead to more complications can be decreased by acting early and consistently.[11] Overall treatment depends on preventing kidney failure (renal failure) which is done by rehydrating the patient. It also depends on making urine have a more basic pH (alkalinization of urine).[11]
Immediate untreated crush syndrome death is caused by severe head injury, torso injury with damaged abdominal organs, and asphyxia (excessive loss of oxygen). Early untreated crush syndrome death is caused by hyperkalemia and by hypovolemic shock. Late untreated crush syndrome death is caused by renal failure, coagulopathy and hemorrhage, and sepsis.[11]
Due to the risk of crush syndrome, current recommendation to nonprofessional first-aiders (in the UK) is to not release those with a crush injury who have been trapped for more than 15 minutes.[12] Treatment consists of not releasing the tourniquet, overloading the patient with fluid using Dextran 4000 IU, and slow release of pressure. If pressure is released during first aid, then fluid is restricted and an input-output chart for the patient is maintained.[citation needed]
Field management
As mentioned, permissive hypotension (restrictive fluid therapy) is unwise. Careful fluid overload and administration of intravenous
Use of a tourniquet can stall the life-threatening consequences of a crush related injury and can be a second option if the person cannot immediately have the fluids that were lost be medically replaced back into the body. Tourniquet measures should be taken if the person has been entrapped for more than two hours.[14]
Initial hospital management
The clinician must protect the patient against
Intravenous hydration of up to 1.5 L/h should continue to prevent hypotension. A urinary output of at least 300 mL/h should be maintained with IV fluids and mannitol, and hemodialysis considered if an increase in urine is not achieved. Use intravenous sodium bicarbonate to keep the urine pH at 6.5 or greater, to prevent myoglobin and uric acid deposition in kidneys.
To prevent hyperkalemia/hypocalcemia, consider the following adult doses:[1]
- calcium gluconate 10% 10 mL or calcium chloride 10% 5 mL IV over 2 minutes
- sodium bicarbonate 1 meq/kg IV slow push
- regular insulin 5–10 U
- 50% glucose 1–2 ampules IV bolus
- kayexalate25–50 g with sorbitol 20% 100 mL by mouth or rectum.
Even so, abnormal heart rhythms may develop; electrocardiographic monitoring is advised, and specific treatment begun promptly.
References
- ^ Centers for Disease Control. Archived from the original (PDF) on 2016-03-04. Retrieved 2015-01-19.)
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(help - ^ S2CID 28949830.
- ^ Medical discoveries - Who and when- Schmidt JF. Springfield: CC Thomas, 1959. p.115.
- ^ Morton's medical bibliography -An annotated check-list of texts illustrating History of medicine (Garrison-Morton). Aldershot: Solar Press; 1911. p.654.
- Who Named It?
- PMID 20783577.
- ISBN 9780763742393.
- ISBN 978-3-319-29120-8.
- ^ "Compartment Syndrome - The 5 Ps". Ausmed. 17 May 2016. Archived from the original on 13 September 2022. Retrieved 6 January 2020.
- PMID 23908797.
- ^ a b c d Smith, Jason (23 October 2002). "Crush Injury and Crush Syndrome". Ovid. 54.
- ^ St John Ambulance UK First Aid Manual, 10th Edition, p. 118
- ^ "Crush Syndrome" (PDF). San Francisco Emergency Medical Services Agency. 1 July 2002. Protocol: #P-101. Archived from the original (PDF) on 28 October 2011.
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(help) - ^ Walters, Thomas (28 December 2016). "Crush Syndrome - Prolonged Field Care" (PDF). Joint Trauma System Clinical Practice Guideline. Archived from the original (PDF) on 21 June 2022.
- Sever MS, Vanholder R, Lameire N (2006). "Management of crush-related injuries after disasters". PMID 16525142.