Cyprodime

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Cyprodime
Structural formula
Ball-and-stick model
Clinical data
Other namesCyprodime
ATC code
  • none
Identifiers
  • (–)-N-(Cyclopropylmethyl)-4,14-dimethoxymorphinan-6-one
JSmol)
  • O=C4CC[C@@]3(OC)[C@@H]2N(CC[C@]3(c1c(cccc1OC)C2)C4)CC5CC5
  • InChI=1S/C22H29NO3/c1-25-18-5-3-4-16-12-19-22(26-2)9-8-17(24)13-21(22,20(16)18)10-11-23(19)14-15-6-7-15/h3-5,15,19H,6-14H2,1-2H3/t19-,21-,22+/m0/s1 ☒N
  • Key:INUCRGMCKDQKNA-ILWGZMRPSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Cyprodime is an

antagonist from the morphinan
family of drugs.

Cyprodime is a selective opioid antagonist which blocks the

κ-opioid receptors. This makes it useful for scientific research as it allows the μ-opioid receptor to be selectively deactivated so that the actions of the δ and κ receptors can be studied separately, in contrast to better known opioid antagonists such as naloxone which block all three opioid receptor subtypes.[2]

See also

  • Tianeptine, an atypical, selective MOR full-agonist licensed for major depression since 1989.
  • Samidorphan, an opioid antagonist preferring the MOR, which is under development for major depression.

References

  1. PMID 2536439
    .
  2. PMID 10585536
    .


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