DBX2
| DBX2 | |||
|---|---|---|---|
| Identifiers | |||
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
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| UniProt |
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| RefSeq (mRNA) | |||||||||
| RefSeq (protein) |
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| Location (UCSC) | Chr 12: 45.01 – 45.05 Mb | Chr 15: 95.52 – 95.55 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Homeobox protein DBX2, also known as developing brain homeobox protein 2, is a protein that in humans is encoded by the DBX2 gene.[5][6] DBX2 plays an important role in the development of the central nervous system, specifically in the development of the neural tube and brain.[7] DBX2 is located on chromosome 12 and is approximately 36,000 base pairs long. DBX2 is predicted to enable DNA-binding transcription activity as well as being involved in the regulation of transcription by RNA polymerase II.[8]
Identification
Dbx (developing brain homeobox) was first isolated from a gestational day 13.5 mouse in 1992.[9] There are two Dbx genes (DBX1 and DBX2) which are both important for development of the central nervous system. DBX2 shows conserved expression patterns in the developing brain and spinal cord and plays an important role in neural patterning and differentiation.
Associated Diseases
DBX2 has been found to play an important role in the development of Glioblastoma which is a lethal brain cancer with poor prognosis.[10] A high expression of DBX2 has been linked to large tumor size in Hepatocellular Carcinoma (HCC)[11] while a downregulated expression of DBX2 has been associated with Endometrial Cancer (EC).[12]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000185610 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000045608 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: developing brain homeobox 2".
- S2CID 2647092.
- PMID 21806971.
- ^ "DBX2 Gene - GeneCards | DBX2 Protein | DBX2 Antibody". www.genecards.org. Retrieved 2022-04-01.
- PMID 1355604.
- S2CID 237364818.
- PMID 30833799.
- PMID 34150054.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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