DFMDA

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DFMDA
Clinical data
ATC code
  • none
Legal status
Legal status
Identifiers
  • 1-(2,2-Difluoro-1,3-benzodioxol-5-yl)propan-2-amine
JSmol)
  • CC(Cc1ccc2c(c1)OC(O2)(F)F)N
  • InChI=1S/C10H11F2NO2/c1-6(13)4-7-2-3-8-9(5-7)15-10(11,12)14-8/h2-3,5-6H,4,13H2,1H3
  • Key:BHDXKBALNFHXDV-UHFFFAOYSA-N
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Difluoromethylenedioxyamphetamine (DFMDA, DiFMDA) is a substituted derivative of

alpha-methyldopamine, it was hoped that the difluoromethylenedioxy bioisostere would show increased metabolic stability and less toxicity.[1][2][3]

These compounds have not yet been tested in animals to verify whether they show similar pharmacological activity to the non-fluorinated parent compounds, although in vitro binding studies show DFMDA to have a SERT affinity in between that of MDA and MDMA.[4] It is also now generally accepted that MDMA neurotoxicity results from a variety of different causes and is not solely due to accumulation of alpha-methyldopamine,[5][6][7] making it unclear how much less neurotoxic DFMDA and related drugs would be in practice.

References

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