DLX4
| DLX4 | |||
|---|---|---|---|
| Identifiers | |||
Gene ontology | |||
| Molecular function |
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| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
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| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 17: 49.97 – 49.97 Mb | Chr 11: 95.03 – 95.04 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Homeobox protein DLX-4 is a protein that in humans is encoded by the DLX4 gene.[5]
Function
Many vertebrate
beta-globin gene while the other isoform lacks that function.[5]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000108813 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020871 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: DLX4 distal-less homeobox 4".
Further reading
- Nakamura S, Stock DW, Wydner KL, Bollekens JA, Takeshita K, Nagai BM, Chiba S, Kitamura T, Freeland TM (1997). "Genomic analysis of a new mammalian distal-less gene: Dlx7". Genomics. 38 (3): 314–24. PMID 8975708.
- Quinn LM, Johnson BV, Nicholl J, Sutherland GR, Kalionis B (1997). "Isolation and identification of homeobox genes from the human placenta including a novel member of the Distal-less family, DLX4". Gene. 187 (1): 55–61. PMID 9073066.
- Morasso MI, Yonescu R, Griffin CA, Sargent TD (1997). "Localization of human DLX8 to chromosome 17q21.3-q22 by fluorescence in situ hybridization". Mamm. Genome. 8 (4): 302–3. S2CID 7448287.
- Price JA, Bowden DW, Wright JT, Pettenati MJ, Hart TC (1998). "Identification of a mutation in DLX3 associated with tricho-dento-osseous (TDO) syndrome". Hum. Mol. Genet. 7 (3): 563–9. PMID 9467018.
- Quinn LM, Latham SE, Kalionis B (1998). "A distal-less class homeobox gene, DLX4, is a candidate for regulating epithelial-mesenchymal cell interactions in the human placenta". Placenta. 19 (1): 87–93. PMID 9481790.
- Quinn LM, Kilpatrick LM, Latham SE, Kalionis B (1998). "Homeobox genes DLX4 and HB24 are expressed in regions of epithelial-mesenchymal cell interaction in the adult human endometrium". Mol. Hum. Reprod. 4 (5): 497–501. PMID 9665637.
- Quinn LM, Latham SE, Kalionis B (2000). "The homeobox genes MSX2 and MOX2 are candidates for regulating epithelial-mesenchymal cell interactions in the human placenta". Placenta. 21 Suppl A: S50–4. PMID 10831122.
- Haga SB, Fu S, Karp JE, Ross DD, Williams DM, Hankins WD, Behm F, Ruscetti FW, Chang M (2000). "BP1, a new homeobox gene, is frequently expressed in acute leukemias". Leukemia. 14 (11): 1867–75. S2CID 24099984.
- Masuda Y, Sasaki A, Shibuya H, Ueno N, Ikeda K, Watanabe K (2001). "Dlxin-1, a novel protein that binds Dlx5 and regulates its transcriptional function". J. Biol. Chem. 276 (7): 5331–8. PMID 11084035.
- Fu S, Stevenson H, Strovel JW, Haga SB, Stamberg J, Do K, Berg PE (2002). "Distinct functions of two isoforms of a homeobox gene, BP1 and DLX7, in the regulation of the beta-globin gene". Gene. 278 (1–2): 131–9. PMID 11707330.
- Sumiyama K, Irvine SQ, Stock DW, Weiss KM, Kawasaki K, Shimizu N, Shashikant CS, Miller W, Ruddle FH (2002). "Genomic structure and functional control of the Dlx3-7 bigene cluster". Proc. Natl. Acad. Sci. U.S.A. 99 (2): 780–5. PMID 11792834.
- Chase MB, Fu S, Haga SB, Davenport G, Stevenson H, Do K, Morgan D, Mah AL, Berg PE (2002). "BP1, a Homeodomain-Containing Isoform of DLX4, Represses the β-Globin Gene". Mol. Cell. Biol. 22 (8): 2505–14. PMID 11909945.
- Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932.
- Neufing PJ, Kalionis B, Horsfall DJ, Ricciardelli C, Stahl J, Vivekanandan S, Raymond W, Tilley WD (2003). "Expression and localization of homeodomain proteins DLX4/HB9 in normal and malignant human breast tissues". Anticancer Res. 23 (2B): 1479–88. PMID 12820413.
- Zoueva OP, Rodgers GP (2004). "Inhibition of beta protein 1 expression enhances beta-globin promoter activity and beta-globin mRNA levels in the human erythroleukemia (K562) cell line". Exp. Hematol. 32 (8): 700–8. PMID 15308321.
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMID 15489334.
- Mpollo MS, Beaudoin M, Berg PE, Beauchemin H, d'Agati V, Trudel M (2006). "BP1 is a negative modulator of definitive erythropoiesis". Nucleic Acids Res. 34 (18): 5232–7. PMID 17003054.
- Murthi P, Said JM, Doherty VL, Donath S, Nowell C, Brennecke S, Kalionis B (2007). "Homeobox gene DLX4 expression is increased in idiopathic human fetal growth restriction". Mol. Hum. Reprod. 12 (12): 763–9. PMID 17062780.
- Tomida S, Yanagisawa K, Koshikawa K, Yatabe Y, Mitsudomi T, Osada H, Takahashi T (2007). "Identification of a metastasis signature and the DLX4 homeobox protein as a regulator of metastasis by combined transcriptome approach". Oncogene. 26 (31): 4600–8. PMID 17260014.
External links
- DLX4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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