DRACO
DRACO (
As of January 2014[update], work had moved to
In 2015, an independent research group reported to have successfully observed antiviral activity against the
As of December 2015[update], research related to DRACOs had ground to a halt due to a lack of funding.[7]
In July 2020, a paper from another independent research group about the effects of DRACO in vitro was published. According to the study, DRACO was nontoxic in uninfected mammalian cells, and cells infected with H1N1 influenza virus showed a "significant", dose-dependent level of apoptosis. [8]
In August 2020 a company called Kimer Med in New Zealand started developing VTose, a derivative of DRACO. [9]
Introduction
There are very few therapies or prophylactics for serious viruses, but for the ones that do exist, they can be divided into 3 categories:
- Special inhibitors of a virus-associated target (e.g. HIV protease inhibitors, RNAi)[1]
- Vaccines, but vaccines require modification for each new virus or viral strain.
- Interferons, but they are less virus specific and are only receptive to certain viruses.
So in order to overcome these obstacles the antiviral DRACO was developed.
Mechanism
DRACO is selective for
It has been shown that DRACOs are nontoxic in 11 mammalian cells types and effective against 15 different viruses.[1]
References
- ^ PMID 21818340.
- ^ "Todd Rider Joins Draper to Continue Antiviral Therapeutics Development" (Press release). Cambridge, MA. PRWeb. January 8, 2014. Retrieved April 8, 2014.
- ^ "PANACEA broad-spectrum antiviral therapeutics". SENS6 Proceedings. Retrieved 2014-04-11.
- ^ "Dr. Todd Rider from MIT Announces IndieGoGo Campaign to Raise Funds to Test and Optimize DRACOs Against Clinically Relevant Viruses". PRWeb. Retrieved 2015-10-26.
- ^ "DRACO May Be A Cure For All Viral Infections". Indiegogo. Retrieved 2019-10-31.
- S2CID 16178322.)
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ignored (help)CS1 maint: location (link - ^ "This man's potentially huge medical breakthrough can't get funding, so he's trying something desperate". Tech Insider. December 15, 2015.
- .
- ^ "Our Work". Kimer Med. Retrieved 2021-01-30.
External links
- Hegarty, Stephanie (20 December 2011). "Is a cure for the common cold on the way?". BBC News Online.
- "MIT Lincoln Laboratory researchers develop a technique to cure a broad range of viruses". MIT Lincoln Laboratory. August 2011. Archived from the original on 2013-08-23. Retrieved 2012-01-02.
- Rider, T. H.; Zook, C. E.; Boettcher, T. L.; Wick, S. T.; Pancoast, J. S.; Zusman, B. D. (July 2011). "Broad-Spectrum Antiviral Therapeutics". PLOS ONE. 6 (7). PMID 21818340.
- Rider, Todd (September 2013). PANACEA broad-spectrum antiviral therapeutics. SENS6 Conference. SENS Foundation(published February 19, 2014). Retrieved April 17, 2014.
- Rider, Todd (October 2015). "DRACOs May Be Effective Against All Viruses". Indiegogo campaign. Retrieved October 30, 2015.
- Rider, Todd (October 2016). "Dr Todd Rider's official website in regards to DRACO". Rider Institute. Retrieved October 9, 2016.