Decoy receptor 3
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DcR3
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Decoy receptor 3 (Dcr3), also known as tumor necrosis factor receptor superfamily member 6B (TNFRSF6B), TR6 and M68, is a soluble protein of the
Discovery
Dcr3 was identified in 1998 by the search of genes with homology to the TNFR gene superfamily in expressed sequence tag (EST) database.
Structure
The open reading frame of TNFRSF6B encodes 300 amino acids with a 29-residue signal sequence and four tandem cystein-rich repeats. Two transcript variants encoding the same isoform, but differing in the 5' UTR, have been observed for this gene.[5] Unlike most of the other members of TNFR superfamily, TNFRSF6 is a soluble protein which contains no transmembrane domain.
Function
This gene belongs to the
TL1A. Overexpression of this gene has been noted in various tumors e.g. gastrointestinal tract tumors, and it is located in a gene-rich cluster on chromosome 20, with other potentially tumor-related genes.[5]
Interactions
TNFRSF6B has been shown to
interact
with:
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000243509 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ S2CID 4427455.
- ^ PMID 10318773.
- ^ a b c "Entrez Gene: TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy".
- PMID 11390428.
- ^ PMID 11994433.
Further reading
- Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. PMID 10470851.
- Bai C, Connolly B, Metzker ML, et al. (2000). "Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster". Proc. Natl. Acad. Sci. U.S.A. 97 (3): 1230–5. PMID 10655513.
- Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. PMID 11780052.
- Migone TS, Zhang J, Luo X, et al. (2002). "TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator". Immunity. 16 (3): 479–92. PMID 11911831.
- Hsu TL, Chang YC, Chen SJ, et al. (2002). "Modulation of dendritic cell differentiation and maturation by decoy receptor 3". J. Immunol. 168 (10): 4846–53. PMID 11994433.
- Mild G, Bachmann F, Boulay JL, et al. (2002). "DCR3 locus is a predictive marker for 5-fluorouracil-based adjuvant chemotherapy in colorectal cancer". Int. J. Cancer. 102 (3): 254–7. S2CID 23680078.
- Gill RM; Ni J; Hunt JS (2003). "Differential Expression of LIGHT and Its Receptors in Human Placental Villi and Amniochorion Membranes". Am. J. Pathol. 161 (6): 2011–7. PMID 12466117.
- Wan X, Zhang J, Luo H, et al. (2003). "A TNF family member LIGHT transduces costimulatory signals into human T cells". J. Immunol. 169 (12): 6813–21. PMID 12471113.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932.
- Wan X, Shi G, Semenuk M, et al. (2003). "DcR3/TR6 modulates immune cell interactions". J. Cell. Biochem. 89 (3): 603–12. S2CID 39322989.
- Tsuji S, Hosotani R, Yonehara S, et al. (2003). "Endogenous decoy receptor 3 blocks the growth inhibition signals mediated by Fas ligand in human pancreatic adenocarcinoma" (PDF). Int. J. Cancer. 106 (1): 17–25. S2CID 34900944.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. PMID 12975309.
- Shi G; Wu Y; Zhang J; Wu J (2004). "Death decoy receptor TR6/DcR3 inhibits T cell chemotaxis in vitro and in vivo". J. Immunol. 171 (7): 3407–14. PMID 14500635.
- Wu SF, Liu TM, Lin YC, et al. (2004). "Immunomodulatory effect of decoy receptor 3 on the differentiation and function of bone marrow-derived dendritic cells in nonobese diabetic mice: from regulatory mechanism to clinical implication". J. Leukoc. Biol. 75 (2): 293–306. S2CID 14226200.
- Chang YC, Hsu TL, Lin HH, et al. (2004). "Modulation of macrophage differentiation and activation by decoy receptor 3". J. Leukoc. Biol. 75 (3): 486–94. S2CID 31939119.
- Kim S, McAuliffe WJ, Zaritskaya LS, et al. (2004). "Selective Induction of Tumor Necrosis Receptor Factor 6/Decoy Receptor 3 Release by Bacterial Antigens in Human Monocytes and Myeloid Dendritic Cells". Infect. Immun. 72 (1): 89–93. PMID 14688085.
- Hsu MJ, Lin WW, Tsao WC, et al. (2004). "Enhanced adhesion of monocytes via reverse signaling triggered by decoy receptor 3". Exp. Cell Res. 292 (2): 241–51. PMID 14697332.
- Gill RM; Hunt JS (2004). "Soluble Receptor (DcR3) and Cellular Inhibitor of Apoptosis-2 (cIAP-2) Protect Human Cytotrophoblast Cells Against LIGHT-Mediated Apoptosis". Am. J. Pathol. 165 (1): 309–17. PMID 15215185.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.