Death receptor 4

Source: Wikipedia, the free encyclopedia.
TNFRSF10A
Identifiers
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Ensembl
UniProt
RefSeq (mRNA)

NM_003844

NM_020275

RefSeq (protein)

NP_003835

NP_064671

Location (UCSC)Chr 8: 23.19 – 23.23 MbChr 14: 70 – 70.02 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Death receptor 4 (DR4), also known as TRAIL receptor 1 (TRAILR1) and tumor necrosis factor receptor superfamily member 10A (TNFRSF10A), is a

TNF-receptor superfamily that binds TRAIL and mediates apoptosis.[5][6]

Function

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis.[7]

Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.[8]

Interactions

TNFRSF10A has been shown to

interact with DAP3.[9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000104689 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022074 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. PMID 9311998
    .
  6. .
  7. ^ "Entrez Gene: TNFRSF10A tumor necrosis factor receptor superfamily, member 10a".
  8. PMID 10862756
    .
  9. .

Further reading