Delapril

Source: Wikipedia, the free encyclopedia.
Delapril
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
  • 2-[2,3-dihydro-1H-inden-2-yl-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]amino]acetic acid
JSmol)
  • O=C(OCC)[C@@H](N[C@H](C(=O)N(CC(=O)O)C2Cc1ccccc1C2)C)CCc3ccccc3
  • InChI=1S/C26H32N2O5/c1-3-33-26(32)23(14-13-19-9-5-4-6-10-19)27-18(2)25(31)28(17-24(29)30)22-15-20-11-7-8-12-21(20)16-22/h4-12,18,22-23,27H,3,13-17H2,1-2H3,(H,29,30)/t18-,23-/m0/s1 ☒N
  • Key:WOUOLAUOZXOLJQ-MBSDFSHPSA-N ☒N
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Delapril (

antihypertensive drug[1] in some European and Asian countries but not in America.[2] It is taken orally, available in 15 mg and 30 mg tablets.[3]

Mechanism

Delapril is a prodrug; it is converted into two active metabolites, 5-hydroxy delapril diacid and delapril diacid. These metabolites bind completely to and inhibit angiotensin-converting enzyme (ACE), hence blocking angiotensin I to angiotensin II conversion. The resulting vasodilation prevents the vasoconstrictive effects of angiotensin II. Angiotensin II-induced aldosterone secretion by the adrenal cortex is also decreased by Delapril, leading to increases in excretion of sodium and therefore increases water outflow.[4]

References

  1. PMID 17703633
    .
  2. ^ "Delapril". Drugs.com.
  3. ^ "Delapril". cursoenarm.net. Retrieved 2016-08-28.
  4. ^ "Delapril". Pubchem. U.S. National Library of Medicine. Retrieved 2016-08-28.