Delayed onset muscle soreness

Delayed onset muscle soreness (DOMS) is the

The soreness is perceived as a dull, aching pain in the affected muscle, often combined with tenderness and stiffness. The pain is typically felt only when the muscle is stretched, contracted or put under pressure, not when it is at rest.[2]^: 63 This tenderness, a characteristic symptom of DOMS, is also referred to as "muscular mechanical hyperalgesia".^[3]

Although there is variance among exercises and individuals, the soreness usually increases in intensity in the first 24 hours after exercise. It peaks from 24 to 72 hours, then subsides and disappears up to seven days after exercise.^[2]: 63

Cause

Muscle soreness is caused by eccentric exercise, that is, exercise consisting of eccentric (lengthening) contractions of the muscle. Isometric (static) exercise causes much less soreness, and concentric (shortening) exercise causes none.^[2]: 63

Mechanism

The mechanism of delayed onset muscle soreness is not completely understood, but the pain is ultimately thought to be a result of microtrauma — mechanical damage at a very small scale — to the muscles being exercised.

DOMS was first described in 1902 by

An earlier theory posited that DOMS is connected to the build-up of lactic acid in the blood, which was thought to continue being produced following exercise. This build-up of lactic acid was thought to be a toxic metabolic waste product that caused the perception of pain at a delayed stage. This theory has been largely rejected, as concentric contractions which also produce lactic acid have been unable to cause DOMS.^[5] Additionally, lactic acid is known from multiple studies to return to normal levels within one hour of exercise, and therefore cannot cause the pain that occurs much later.^[7]

Mizumura et al. argue, in contrast to the conventional view, that muscle damage is a sufficient but not necessary condition for DOMS, and that a crucial role is played by the activation of the B2 bradykinin receptor–nerve growth factor (NGF) and the COX-2-glial cell line-derived neurotrophic factor (GDNF) pathways.^[10] A recent theory of Sonkodi et al., that incorporates the findings of Mizumura et al., proposes that the microdamage to the muscles is only the secondary phase of DOMS injury mechanism and suggests that the primary damage is the microinjury of the proprioceptive Type Ia sensory fiber terminals within the muscle spindle.^[11]

Relation to other effects

Although delayed onset muscle soreness is a symptom associated with muscle damage, its magnitude does not necessarily reflect the magnitude of muscle damage.^{[2]: 66–67}

Soreness is one of the temporary changes caused in muscles by unaccustomed eccentric exercise. Other such changes include decreased muscle strength, reduced range of motion, and muscle swelling.^[2]: 66 It has been shown, however, that these changes develop independently in time from one another and that the soreness is therefore not the cause of the reduction in muscle function.^[2]: 66

Possible function as a warning sign

Soreness might conceivably serve as a warning to reduce muscle activity to prevent injury or further injury. With delayed onset muscle soreness (DOMS) caused by eccentric exercise (muscle lengthening), it was observed that light concentric exercise (muscle shortening) during DOMS can cause initially more pain but was followed by a temporary alleviation of soreness with no adverse effects on muscle function or recovery being observed.^[2]: 68 Furthermore, eccentric exercise during DOMS was found to not exacerbate muscle damage, nor did it have an adverse effect on recovery, indicating that soreness is not necessarily a warning sign to reduce the usage of the affected muscle.^[2]: 68 However, it was also observed that a second bout of eccentric exercise within one week of the initial exercise did lead to decreased muscle function immediately afterward.^[2]: 70

Repeated-bout effect

After performing an unaccustomed eccentric exercise and exhibiting severe soreness, the muscle rapidly adapts to reduce further damage from the same exercise. This is called the "repeated-bout effect".^[12]

As a result of this effect, not only is the soreness reduced the next time the exercise is performed, but other indicators of muscle damage, such as swelling, reduced strength, and reduced range of motion, are also more quickly recovered from. The effect is mostly, but not wholly, specific to the exercised muscle; experiments have shown that some of the protective effects is also conferred on other muscles.^[2]: 69

The magnitude of the effect is subject to many variations, depending for instance on the time between bouts, the number and length of eccentric contractions, and the exercise mode. It also varies between people and between indicators of muscle damage.^[2]: 69 Generally, though, the protective effect lasts for at least several weeks. It seems to gradually decrease as the time between bouts increases and is undetectable after about one year.^[2]: 70

The first bout does not need to be as intense as the subsequent bouts to confer at least some protection against soreness. For instance, eccentric exercise performed at 40% of maximal strength has been shown to confer a protection of 20 to 60% from muscle damage incurred by a 100% strength exercise two to three weeks later.^[2]: 73 Also, the repeated-bout effect appears even after a relatively small number of contractions, possibly as few as two. In one study, a first bout of 10, 20 or 50 contractions provided equal protection for a second bout of 50 contractions three weeks later.^[2]: 70

The reason for the protective effect is not yet understood. A number of possible mechanisms, which may complement one another, have been proposed. These include neural adaptations (improved use and control of the muscle by the nervous system), mechanical adaptations (increased muscle stiffness or muscle support tissue), and cellular adaptations (adaptation to inflammatory response and increased

Delayed onset muscle soreness can be reduced or prevented by gradually increasing the intensity of a new exercise program,[13]^: 112 thereby taking advantage of the repeated-bout effect.^[14]

Soreness can theoretically be avoided by limiting exercise to concentric and isometric contractions,^[13]: 112 but eccentric contractions in some muscles are normally unavoidable during exercise, especially when muscles are fatigued.^[2]: 63 Limiting the length of eccentric muscle extensions during exercise may afford some protection against soreness, but this may also not be practical depending on the mode of exercise.

Physical activity before eccentric exercise helps to prevent delayed-onset muscle soreness.

Other preventative measures with evidence of efficacy based on randomized controlled trials include the consumption of saffron.^[19] Wearing compression garments has not been demonstrated to have a significant effect on delayed onset muscle soreness.^[20]

Treatment

The soreness usually disappears within about 72 hours after appearing. If treatment is desired, any measure that increases blood flow to the muscle, such as low-intensity activity, massage, nerve mobilization,^[21] hot baths,^[22][23] or a sauna visit may help somewhat.^[13]: 112

Immersion in cool or icy water, an occasionally recommended remedy, was found to be ineffective in alleviating DOMS in one 2011 study,^[24] but effective in another.^[25] There is also insufficient evidence to determine whether whole-body cryotherapy — compared with passive rest or no whole-body cryotherapy — reduces DOMS, or improves subjective recovery, after exercise.^[1]

Counterintuitively, continued exercise may temporarily suppress the soreness. Exercise increases pain thresholds and pain tolerance. This effect, called

Ibuprofen is not an appropriate treatment for delayed onset muscle soreness and damage.^[26] It decreases soreness, but does not counteract the reduction in muscular performance caused by delayed onset muscle soreness.^[27]

References