Depot injection
A depot injection is a term for an
Purpose
Depot injections provide longer duration drug action through slow absorption into the bloodstream. They are usually administered
Mechanism
Drugs may be modified to be slowly activated by the body, or be absorbed slowly by the body. Many are dissolved in an organic oil, as the compound is
The alteration of the
Discovery
The first long-acting (depot) injections were antipsychotics fluphenazine and haloperidol.[2] The concept of a depot injection arose before 1950, and originally was used to describe antibiotic injections that lasted longer to allow for less frequent administration.[4]
Pharmacokinetics
Most commonly, depot injections are designed to have a duration of 2–4 weeks of action,
Hormonal depot injections of estradiol can last anywhere from one week to over one month.[7] Medroxyprogesterone acetate is available as a depot injection which is injected once every three months to provide continuous hormonal contraception and releases for up to nine months after injection.[8]
Availability
Many medications are available as depot injections, including many typical and atypical antipsychotics,
See also
References
- ^ S2CID 220412843.
- ^ a b c d Kennedy, WK (2012). "When and how to use long-acting injectable antipsychotics". Current Psychiatry. 11 (8): 40–43.
- ^ a b c Carpenter, J; Wong, KK (2018). "Long-acting injectable antipsychotics: What to do about missed doses". Current Psychiatry. 17 (7): 10–12, 14–19, 56.
- PMID 18109791.
- ^ ISBN 978-1-4614-0554-2.
- PMID 444352.
- PMID 7389356.
- PMID 8725700.
- ^ S2CID 9835921.
- PMID 32389457.
- S2CID 211213131.
- ^ PMID 29706227.
- PMID 30369394.
- PMID 23208858.