Deutetrabenazine
Clinical data | |
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Trade names | Austedo |
Other names | Tetrabenazine D6; SD809; SD-809 |
AHFS/Drugs.com | Monograph |
MedlinePlus | a617022 |
License data | |
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Routes of administration | By mouth |
ATC code | |
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Chemical and physical data | |
Formula | C19H21D6NO3 |
Molar mass | 323.462 g·mol−1 |
Deutetrabenazine (trade name Austedo) is a vesicular monoamine transporter 2 inhibitor which is used for the treatment of chorea associated with Huntington's disease and tardive dyskinesia.
Chemically, deutetrabenazine is an
Efficacy
A Lancet study published on 28 June 2017 carried out a review between 29 October 2014 and 19 August 2016 where 298 patients were randomly assigned to receive at least one of the following: one dose of placebo per day, one dose of deutetrabenazine 12 mg/day, one dose of deutetrabenazine 24 mg/day, or one dose of deutetrabenazine 36 mg/day. From baseline to week 12, the least-squares mean AIMS (Abnormal Involuntary Movement Scale) score improved by −3.3 points in the deutetrabenazine 36 mg/day group, −3.2 points in the 24 mg/day group, −2.1 points in the 12 mg/day group, and −1.4 points in the placebo group. Deutetrabenazine 24 mg/day and 36 mg/day provided a significant reduction in tardive dyskinesia, with favourable safety and tolerability. These findings suggest that dosing regimens could be individualized and tailored for patients on the basis of dyskinesia control and tolerability.[7]
Pharmacology
Pharmacodynamics
Deutetrabenazine acts as a monoamine-depleting agent.[citation needed]
History
See also
References
- ^ a b "Austedo". Therapeutic Goods Administration (TGA). 9 June 2021. Archived from the original on 6 September 2021. Retrieved 6 September 2021.
- FDA. Retrieved 22 October 2023.
- ^ "AusPAR: Deutetrabenazine". Therapeutic Goods Administration (TGA). 27 May 2022. Archived from the original on 27 May 2022. Retrieved 13 June 2022.
- ^ Anvisa (31 March 2023). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 4 April 2023). Archived from the original on 3 August 2023. Retrieved 16 August 2023.
- from the original on 21 August 2020. Retrieved 4 April 2017.
- PMID 27988871.
- from the original on 28 August 2021. Retrieved 4 February 2018.
- ^ "FDA Approves Drug for Huntington's Disease". 3 April 2017. Archived from the original on 23 January 2019. Retrieved 4 April 2017.
- S2CID 205269152.
- ^ "FDA Determines that Deuterated Compounds are NCEs and Different Orphan Drugs Versus Non-deuterated Versions". FDA Law Blog. 16 July 2017. Archived from the original on 7 November 2017. Retrieved 5 November 2017.
Further reading
- Dean L (May 2019). "Deutetrabenazine Therapy and CYP2D6 Genotype". In Pratt VM, McLeod HL, Rubinstein WS, et al. (eds.). Medical Genetics Summaries. PMID 31046213.
External links
- "Deutetrabenazine". Drug Information Portal. U.S. National Library of Medicine.