Development of the digestive system
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The development of the digestive system in the
Body cavities
At the end of the third week, the
The lateral body wall folds, pulling the
Rotation and herniation
In the process of lengthening growth, the intestinal duct herniates and rotates. Herniation (Latin, meaning 'rupture') takes place at around 7½ weeks in the human embryo and refers to the retraction of the intestine from the extraembryonal navel coelom into the abdomen (panel B3).
The intestinal duct rotates by 90° (counterclockwise when viewing from tail-to-head) around the boy axis (see panel B1) in the same direction as the
Folding occurs in a typical manner as shown in the diagram (panel B2-3, C). The folding is a result of the elongation of the duct.
Diaphragm and thoracic cavity
The
Divisions of the gut tube
As a result of the cephalocaudal and lateral folding of the embryo, a portion of the endoderm-lined yolk sac cavity is incorporated into the embryo to form the primitive gut. In the
Foregut
The foregut gives rise to the esophagus, the trachea, lung buds, the stomach, and the duodenum proximal to the entrance of the bile duct. In addition, the liver, pancreas, and biliary apparatus develop as outgrowths of the endodermal epithelium of the upper part of the duodenum. Since the upper part of the foregut is divided by the tracheoesophageal septum into the esophagus posteriorly and the trachea and lung buds anteriorly, deviation of the septum may result in abnormal openings between the trachea and esophagus. The epithelial liver cords and biliary system growing out into the septum transversum differentiate into parenchyma. Hematopoietic cells (present in the liver in greater numbers before birth than afterward), Kupffer cells, and connective tissue cells originate in the mesoderm. The pancreas develops from a ventral bud and a dorsal bud that later fuse to form the definitive pancreas. Sometimes, the two parts surround the duodenum (annular pancreas), causing constriction of the gut.[7]
Midgut
The midgut forms the primary intestinal loop, from which originates the distal duodenum to the entrance of the bile duct. The loop continues to the junction of the proximal two-thirds of the transverse colon with the distal third. At its apex, the primary loop remains temporarily in open connection with the yolk sac through the
Hindgut
The hindgut gives rise to the region from the distal third of the
Molecular regulation
Regional specification of the gut tube into different components occurs during the time that the lateral body folds are bringing the two sides of the tube together. Different regions of the gut tube are initiated by retinoic acid (RA) from the pharynx to the colon. This RA causes transcription factors to be expressed in different regions of the gut tube. Thus, SOX2 specifies the esophagus and stomach; PDX1 specifies the duodenum; CDXC specifies the small intestine; CDXA specifies the large intestine and rectum.[9]
The differentiation of the gut and its derivatives depends upon reciprocal interactions between the gut endoderm (epithelium) and its surrounding mesoderm (an epithelial-mesenchymal interaction). Hox genes in the mesoderm are induced by SHH secreted by gut endoderm and regulate the craniocaudal organization of the gut and its derivatives. Once the mesoderm is specified by this code, it instructs the endoderm to form components of the mid- and hindgut regions, such as the small intestine, caecum, colon, and cloaca.[1]
Mesentery
Portions of the gut tube and its derivatives are suspended from the dorsal and ventral body wall by mesenteries, double layers of peritoneum that enclose an organ and connect it to the body wall. Such organs are called intraperitoneal, whereas organs that lie against the posterior body wall and are covered by peritoneum on their anterior surface only are considered retroperitoneal. So, mesenteries are double layers of peritoneum that pass from one organ to another or from an organ to the body wall as a peritoneal ligament. Mesenteries provide pathways for vessels, nerves, and lymphatic structures to and from abdominal viscera.[6]
Initially the foregut, midgut, and hindgut are in extensive contact with the
The ventral mesentery, located in the region of the terminal part of the esophagus, the stomach and the upper part of the duodenum, is derived from the septum transversum. Growth of the liver into the mesenchyme of the septum transversum divides the ventral mesentery into the lesser omentum, extending from the lower portion of the esophagus, the stomach, and the upper portion of the duodenum to the liver and the falciform ligament, extending from the liver to the ventral body wall.[6]
See also
References
- ^ a b c Sadler TW, Sadler-Redmond SL (2012). LANGMAN Embriología médica. Vol. I (12 ed.). Philadelphia, PA: The Point.
- ^ Tortora G, Derrickson B (2008). Principios de anatomía y fisiología. Vol. I (11 ed.). Buenos Aires: Panamericana.
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- PMID 31211022.
- ^ a b c d e f Moore K, Agur L (2009). Embriología Clínica Moore. Vol. XI (5th ed.). Madrid: Elsevier Health Sciences.
- ^ Guyton A, Hall J (2011). Guyton y Hall Fisiología Médica. Vol. II (11a ed.). Madrid: Elsevier Health Sciences.
- ^ Boron W, Boulpaep E (2012). Medical Physiology Boron. Vol. II (2nd ed.). Philadelphia: Elsevier Health Sciences.
- ^ Barrett K, Barman S, Boitano S (2010). Ganong Fisiología médica. Vol. X (23rd ed.). New York: Mc Graw Hill.