Dexibuprofen

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Dexibuprofen
Clinical data
Trade namesSeractil, Deltaran, Ibusoft, Monactil
Other namesS(+)Ibuprofen
AHFS/Drugs.comInternational Drug Names
Routes of
administration		Oral
ATC code
Identifiers
  • (2S)-2-[4-(2-methylpropyl)phenyl]propanoic acid
JSmol)
  • C[C@@H](c1ccc(cc1)CC(C)C)C(=O)O
  • InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)/t10-/m0/s1 checkY
  • Key:HEFNNWSXXWATRW-JTQLQIEISA-N checkY
  (verify)

Dexibuprofen is a

dextrorotatory enantiomer of ibuprofen.[1] Most ibuprofen formulations contain a racemic mixture
of both isomers.

Dexibuprofen is a chiral switch of racemic ibuprofen. The chiral carbon in dexibuprofen is assigned an absolute configuration of (S) per the Cahn–Ingold–Prelog rules.[2][3] Dexibuprofen is also called as S(+)Ibuprofen.

Ibuprofen is an α-arylpropionic acid used largely in the treatment of

distomer, undergoes a unidirectional chiral inversion to give the active (S)-enantiomer, the former acting as a prodrug for the latter.[4][5][6][7][8]
That is, when the ibuprofen is administered as a racemate the distomer is converted in vivo into the eutomer while the latter is unaffected.


See also

References

  1. PMID 19552094
    .
  2. ISSN 0570-0833
    .
  3. S2CID 43026989
    .
  4. PMID 3276314
    .
  5. S2CID 40669413
    .
  6. S2CID 38614295
    .
  7. S2CID 43433812
    .
  8. ^ Kannappan V. "Dexibuprofen – Chiralpedia". Retrieved 2022-08-27.
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