Dexketoprofen

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Dexketoprofen
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Legal status
Legal status
  • UK: POM (Prescription only)
Identifiers
  • (2S)-2-[3-(benzoyl)phenyl]propanoic acid
JSmol)
  • C[C@@H](c1cccc(c1)C(=O)c2ccccc2)C(=O)O
  • InChI=1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19)/t11-/m0/s1 ☒N
  • Key:DKYWVDODHFEZIM-NSHDSACASA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Dexketoprofen is a

UK, as dexketoprofen trometamol, as a prescription-only drug and in Latin America as Enantyum, produced by Menarini. Also, in Italy and Spain it is available as an over-the-counter drug (OTC) under the trade name Enandol or Enantyum. In Hungary it is available from a pharmacy as "Ketodex". In Turkey, it is an over the counter medicine under the name "Arveles". In Latvia, Lithuania and Estonia
it is available as an OTC under the tradename Dolmen
stereoisomer of ketoprofen.[2]

Chemistry

Dexketoprofen is the (S)-enantiomer of ketoprofen. Technically it is a chiral switch of (±)-ketoprofen. The switch was done for a faster onset of action, a better therapeutic value.[3] Dexketoprofen consists of a propionic acid moiety connected to a benzophenone molecule by its second carbon.

Medical uses

Short-term treatment of mild to moderate

dysmenorrhoea
. It is also used for migraines and knee pain.

Side effects

It may cause dizziness, and patients should not, therefore, drive or operate heavy machinery or vehicles until they are familiar with how dexketoprofen affects them. Concomitant use of alcohol and other sedatives may potentiate this effect. In a small subset of individuals the dizziness may be intolerable and require transition to an alternative treatment.

Pharmacology

Dexketoprofen belongs to a class of medicines called NSAIDs. It works by blocking the action of a substance in the body called

prostaglandins
. Prostaglandins are produced in response to injury or certain diseases and would otherwise go on to cause swelling, inflammation and pain. By blocking cyclo-oxygenase, dexketoprofen prevents the production of prostaglandins and therefore reduces inflammation and pain. Along with peripheral analgesic action, it possesses central analgesic action.

See also

References

  1. ^ "Medicinal products authorised in Estonia". State Agency of Medicine. 22 May 2014. Retrieved 23 May 2014.
  2. ISBN 978-0-08-055232-3
    .
  3. S2CID 30715334
    .
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