Dihydroetorphine

Source: Wikipedia, the free encyclopedia.
Dihydroetorphine
Clinical data
ATC code
  • none
Legal status
Legal status
Identifiers
  • (5R,6R,7R,9R,13S,14R)-7-[(R)-2-Hydroxypentan-2-yl] -6-methoxy-17-methyl-4,5-epoxy-6,14-ethanomorphinan-3-ol
JSmol)
  • Oc6ccc4c1c6O[C@H]3[C@]5(OC)[C@H](C[C@@]2([C@H](N(CC[C@@]123)C)C4)CC5)[C@@](O)(C)CCC
  • InChI=1S/C25H35NO4/c1-5-8-22(2,28)17-14-23-9-10-25(17,29-4)21-24(23)11-12-26(3)18(23)13-15-6-7-16(27)20(30-21)19(15)24/h6-7,17-18,21,27-28H,5,8-14H2,1-4H3/t17-,18-,21-,22-,23-,24+,25-/m1/s1 checkY
  • Key:BRTSNYPDACNMIP-FAWZKKEFSA-N checkY
  (verify)

Dihydroetorphine was developed by K. W. Bentley at McFarlan-Smith in the 1960s[1] and is a potent opioid analgesic[2] used mainly in China. It is a derivative of the better-known opioid etorphine, a very potent veterinary painkiller and anesthetic medication used primarily for the sedation of large animals such as elephants, giraffes, and rhinos.

Dihydroetorphine is a semi-

respiratory depression can occur. Transdermal patches of dihydroetorphine have also been developed.[4]

Dihydroetorphine is considered to be somewhat less addictive than many other opioids, and it is also sometimes used in China as a substitute maintenance drug for opioid addicts,[5] in a similar fashion to how the related drug buprenorphine is used in western nations.[6][7] It is presumably controlled as an "ester, ether, [or] salt" of etorphine in the United States under the Controlled Substances Act 1970, and/or its pieces of the morphine carbon skeleton put it under the "morphine rule" thereof and/or the 1986 analogues act; it does not have its own ACSCN.[8] Regulation elsewhere may vary but would likely be similar to that for other strong opioid agonists.[citation needed]

Dihydroetorphine is illegal in Italy, as are its parent compounds etorphine and acetorphine.[9]

See also

References

  1. ^
    PMID 6042764
    .
  2. PMID 9788770
    .
  3. PMID 15032698
    .
  4. PMID 12481194
    .
  5. S2CID 201878290. Archived from the original
    on 2013-05-25. Retrieved 2017-09-09.
  6. S2CID 23944183
    .
  7. PMID 12570846
    .
  8. ^ "DEA Diversion Control Division". Archived from the original on 2016-03-02. Retrieved 2016-02-27.
  9. ^ Salute, Ministero della. "Tabelle delle sostanze stupefacenti e psicotrope". www.salute.gov.it (in Italian). Retrieved 2022-04-09.

External links


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